Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test

Marzieh Salehi, Benedict Aulinger, David A. D'Alessio

Producción científica: Articlerevisión exhaustiva

27 Citas (Scopus)

Resumen

The incretin effect, reflecting the enhancement of postprandial insulin secretion by factors including the intestinal hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide, increases in proportion to meal size. However, it is unknown whether the incretin effect is dependent on ambient glucose. The goal of this study was to determine the effect of plasma glycemia on the incretin effect. Thirteen healthy subjects consumed 50 g oral glucose solution mixed with D-xylose during fixed hyperglycemia at 8 and 10.5 mmol/L, on 3 separate days, twice at lower glycemia (LOW) and once at higher values (HIGH). The relative increase in insulin release after glucose ingestion at fixed hyperglycemia, a surrogate for the incretin effect, was similar among all three studies. The GLP-1 response to oral glucose was significantly lower at higher plasma glycemia, as was the appearance of D-xylose after the meal. Between the two LOW studies, the reproducibility of insulin release in response to intravenous glucose alone and intravenous plus ingested glucose was similar. These findings indicate that the incretin contribution to postprandial insulin release is independent of glycemia in healthy individuals, despite differences in GLP-1 secretion. The incretin effect is a reproducible trait among humans with normal glucose tolerance.

Idioma originalEnglish (US)
Páginas (desde-hasta)2728-2733
Número de páginas6
PublicaciónDiabetes
Volumen61
N.º11
DOI
EstadoPublished - nov 2012
Publicado de forma externa

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Huella

Profundice en los temas de investigación de 'Effect of glycemia on plasma incretins and the incretin effect during oral glucose tolerance test'. En conjunto forman una huella única.

Citar esto