Effect of exogenous dopamine on hypothalamic dopamine and norepinephrine concentrations in the neonatal brain in rats

Takeyoshi Ohkura; J. W. Lee; N. Hagino

doi:10.1016/0736-5748(86)90037-7

Effect of exogenous dopamine on hypothalamic dopamine and norepinephrine concentrations in the neonatal brain in rats

Takeyoshi Ohkura, J. W. Lee, N. Hagino

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Resumen

Hypothalamic dopamine (DA) and norepinephrine (NE) concentrations were studied in the neonatal rats after acute (postnatal day 4) or chronic (postnatal days 1-10) DA injections (0.5 mg in 5% dextrose in 0.45% saline). Acute injection of DA twice on postnatal day 4 resulted in an increase of hypothalamic DA and NE concentrations 16 hr later. Chronic treatment with the DA (twice in a day) for 10 days resulted in a reduction of NE concentration in the hypothalamus. The results of these studies suggest that the amount and duration of exposure to exogenous DA during postnatal development may result in divergent effects on hypothalamic catecholamine concentration.

Idioma original	English (US)
Páginas (desde-hasta)	129-133
Número de páginas	5
Publicación	International Journal of Developmental Neuroscience
Volumen	4
N.º	2
DOI	https://doi.org/10.1016/0736-5748(86)90037-7
Estado	Published - 1986
Publicado de forma externa	Sí

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

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@article{e3dd881d01594735960015fd155d11ec,

title = "Effect of exogenous dopamine on hypothalamic dopamine and norepinephrine concentrations in the neonatal brain in rats",

abstract = "Hypothalamic dopamine (DA) and norepinephrine (NE) concentrations were studied in the neonatal rats after acute (postnatal day 4) or chronic (postnatal days 1-10) DA injections (0.5 mg in 5% dextrose in 0.45% saline). Acute injection of DA twice on postnatal day 4 resulted in an increase of hypothalamic DA and NE concentrations 16 hr later. Chronic treatment with the DA (twice in a day) for 10 days resulted in a reduction of NE concentration in the hypothalamus. The results of these studies suggest that the amount and duration of exposure to exogenous DA during postnatal development may result in divergent effects on hypothalamic catecholamine concentration.",

keywords = "Dopamine, Hypothalamus, Neonatal brain, Norepinephrine",

author = "Takeyoshi Ohkura and Lee, {J. W.} and N. Hagino",

note = "Funding Information: Acknowledg~m~nrs-The authors wish to express their gratitude to MS D. Flores for preparatton 01 manuscript. Particularly, Dr Ohkura wishes to express his gratitude for Dr S. Isoda. President of Dokkyo University School of Medicine. Dr T. Kumasaka, Chairman of OB-GYN, Dokkyo University School of Medicine and Dr Tokuko Ohkura for support of his study at The University of Texas Health Science Center at San Antonio. The study was supported by a grant from the Council of Tobacco Research (137-M).",

year = "1986",

doi = "10.1016/0736-5748(86)90037-7",

language = "English (US)",

volume = "4",

pages = "129--133",

journal = "International Journal of Developmental Neuroscience",

issn = "0736-5748",

publisher = "Elsevier Limited",

number = "2",

}

TY - JOUR

T1 - Effect of exogenous dopamine on hypothalamic dopamine and norepinephrine concentrations in the neonatal brain in rats

AU - Ohkura, Takeyoshi

AU - Lee, J. W.

AU - Hagino, N.

N1 - Funding Information: Acknowledg~m~nrs-The authors wish to express their gratitude to MS D. Flores for preparatton 01 manuscript. Particularly, Dr Ohkura wishes to express his gratitude for Dr S. Isoda. President of Dokkyo University School of Medicine. Dr T. Kumasaka, Chairman of OB-GYN, Dokkyo University School of Medicine and Dr Tokuko Ohkura for support of his study at The University of Texas Health Science Center at San Antonio. The study was supported by a grant from the Council of Tobacco Research (137-M).

PY - 1986

Y1 - 1986

N2 - Hypothalamic dopamine (DA) and norepinephrine (NE) concentrations were studied in the neonatal rats after acute (postnatal day 4) or chronic (postnatal days 1-10) DA injections (0.5 mg in 5% dextrose in 0.45% saline). Acute injection of DA twice on postnatal day 4 resulted in an increase of hypothalamic DA and NE concentrations 16 hr later. Chronic treatment with the DA (twice in a day) for 10 days resulted in a reduction of NE concentration in the hypothalamus. The results of these studies suggest that the amount and duration of exposure to exogenous DA during postnatal development may result in divergent effects on hypothalamic catecholamine concentration.

AB - Hypothalamic dopamine (DA) and norepinephrine (NE) concentrations were studied in the neonatal rats after acute (postnatal day 4) or chronic (postnatal days 1-10) DA injections (0.5 mg in 5% dextrose in 0.45% saline). Acute injection of DA twice on postnatal day 4 resulted in an increase of hypothalamic DA and NE concentrations 16 hr later. Chronic treatment with the DA (twice in a day) for 10 days resulted in a reduction of NE concentration in the hypothalamus. The results of these studies suggest that the amount and duration of exposure to exogenous DA during postnatal development may result in divergent effects on hypothalamic catecholamine concentration.

KW - Dopamine

KW - Hypothalamus

KW - Neonatal brain

KW - Norepinephrine

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U2 - 10.1016/0736-5748(86)90037-7

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SN - 0736-5748

VL - 4

SP - 129

EP - 133

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

IS - 2

ER -

Effect of exogenous dopamine on hypothalamic dopamine and norepinephrine concentrations in the neonatal brain in rats

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