Effect of D-Trp6-LH-RH on the pituitary-gonadal axis during the luteal phase in the baboon

An effect of D-Trp6-LH-RH (superactive LH-RH agonist) in the pituitary and ovarian function was examined. Four regularly cycling baboons were used for this study. After determination of control values of plasma levels of LH, oestrogen and progesterone during the entire menstrual cycle, D-Trp6-LH-RH was infused subcutaneously for 7 days during the early luteal phase in these four baboons. An infusion of D-Trp6-LH-RH increased plasma LH and oestrogen, but it failed to alter the plasma level of progesterone. From these results, it seems unlikely that D-Trp6-LH-RH has a luteolytic effect, and an increased ovarian oestrogen causes luteolysis in the baboon.