Effect of cimetidine on gastric secretory function during stress

Barry A. Levine; Kenneth R. Sirinek; David K. Teegarden; Charles G. McLoed; Basil A. Pruitt

doi:10.1016/0022-4804(78)90171-3

Effect of cimetidine on gastric secretory function during stress

Barry A. Levine, Kenneth R. Sirinek, David K. Teegarden, Charles G. McLoed, Basil A. Pruitt

Producción científica: Article › revisión exhaustiva

6 Citas (Scopus)

Resumen

This study evaluated the effect of cimetidine, an H₂-receptor antagonist, on gastric acid secretion in awake stressed and nonstressed rats with chronic gastric fistulas. The findings were: 1. (1) Cimetidine decreased total gastric acid output in stressed and nonstressed animals compared to controls. 2. (2) Cimetidine decreased gastric acid concentration in stressed and nonstressed animals compared to controls. 3. (3) Control stressed rats demonstrated reduced total gastric acid output but unchanged acid concentration compared to nonstressed controls. Conclusions were: 1. (1) Gastric acid concentration is more important than total acid output in formation of stress-related gastric mucosal injury. 2. (2) Cimetidine's protective role in stress is related to its ability to decrease gastric acid concentration.

Idioma original	English (US)
Páginas (desde-hasta)	178-181
Número de páginas	4
Publicación	Journal of Surgical Research
Volumen	24
N.º	3
DOI	https://doi.org/10.1016/0022-4804(78)90171-3
Estado	Published - mar 1978
Publicado de forma externa	Sí

ASJC Scopus subject areas

Surgery

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title = "Effect of cimetidine on gastric secretory function during stress",

abstract = "This study evaluated the effect of cimetidine, an H2-receptor antagonist, on gastric acid secretion in awake stressed and nonstressed rats with chronic gastric fistulas. The findings were: 1. (1) Cimetidine decreased total gastric acid output in stressed and nonstressed animals compared to controls. 2. (2) Cimetidine decreased gastric acid concentration in stressed and nonstressed animals compared to controls. 3. (3) Control stressed rats demonstrated reduced total gastric acid output but unchanged acid concentration compared to nonstressed controls. Conclusions were: 1. (1) Gastric acid concentration is more important than total acid output in formation of stress-related gastric mucosal injury. 2. (2) Cimetidine's protective role in stress is related to its ability to decrease gastric acid concentration.",

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year = "1978",

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doi = "10.1016/0022-4804(78)90171-3",

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AU - Levine, Barry A.

AU - Sirinek, Kenneth R.

AU - Teegarden, David K.

AU - McLoed, Charles G.

AU - Pruitt, Basil A.

PY - 1978/3

Y1 - 1978/3

N2 - This study evaluated the effect of cimetidine, an H2-receptor antagonist, on gastric acid secretion in awake stressed and nonstressed rats with chronic gastric fistulas. The findings were: 1. (1) Cimetidine decreased total gastric acid output in stressed and nonstressed animals compared to controls. 2. (2) Cimetidine decreased gastric acid concentration in stressed and nonstressed animals compared to controls. 3. (3) Control stressed rats demonstrated reduced total gastric acid output but unchanged acid concentration compared to nonstressed controls. Conclusions were: 1. (1) Gastric acid concentration is more important than total acid output in formation of stress-related gastric mucosal injury. 2. (2) Cimetidine's protective role in stress is related to its ability to decrease gastric acid concentration.

AB - This study evaluated the effect of cimetidine, an H2-receptor antagonist, on gastric acid secretion in awake stressed and nonstressed rats with chronic gastric fistulas. The findings were: 1. (1) Cimetidine decreased total gastric acid output in stressed and nonstressed animals compared to controls. 2. (2) Cimetidine decreased gastric acid concentration in stressed and nonstressed animals compared to controls. 3. (3) Control stressed rats demonstrated reduced total gastric acid output but unchanged acid concentration compared to nonstressed controls. Conclusions were: 1. (1) Gastric acid concentration is more important than total acid output in formation of stress-related gastric mucosal injury. 2. (2) Cimetidine's protective role in stress is related to its ability to decrease gastric acid concentration.

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Effect of cimetidine on gastric secretory function during stress

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