Dose-response effect of eribulin in preclinical models of osteosarcoma by the pediatric preclinical testing consortium

Jonathan Gill; Wendong Zhang; Zhongting Zhang; Michael Roth; Douglas J. Harrison; Sudie Rowshan; Stephen Erickson; Gregory Gatto; Raushan Kurmasheva; Peter Houghton; Beverly Teicher; Malcolm A. Smith; E. Anders Kolb; Richard Gorlick

doi:10.1002/pbc.28606

Dose-response effect of eribulin in preclinical models of osteosarcoma by the pediatric preclinical testing consortium

Jonathan Gill, Wendong Zhang, Zhongting Zhang, Michael Roth, Douglas J. Harrison, Sudie Rowshan, Stephen Erickson, Gregory Gatto, Raushan Kurmasheva, Peter Houghton, Beverly Teicher, Malcolm A. Smith, E. Anders Kolb, Richard Gorlick

Producción científica: Article › revisión exhaustiva

8 Citas (Scopus)

Resumen

The pediatric preclinical testing program previously demonstrated activity of eribulin in osteosarcoma patient-derived xenograft (PDX) models. The phase 2 trial in patients with relapsed osteosarcoma failed to meet response endpoints. Eribulin was evaluated in the original and an expanded set of PDX models and tested at multiple dose levels and schedules to evaluate dose-response. Maximal response was observed at the highest dose, consistent with prior results. The alternative schedule generated similar responses. We demonstrate steep dose-response for eribulin in osteosarcoma PDX models, implying that any deviation from achievement of effective concentrations may have a significant impact on activity.

Idioma original	English (US)
Número de artículo	e28606
Publicación	Pediatric Blood and Cancer
Volumen	67
N.º	10
DOI	https://doi.org/10.1002/pbc.28606
Estado	Published - oct 1 2020

ASJC Scopus subject areas

Hematology
Oncology
Pediatrics, Perinatology, and Child Health

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Gill, J., Zhang, W., Zhang, Z., Roth, M., Harrison, D. J., Rowshan, S., Erickson, S., Gatto, G., Kurmasheva, R., Houghton, P., Teicher, B., Smith, M. A., Kolb, E. A., & Gorlick, R. (2020). Dose-response effect of eribulin in preclinical models of osteosarcoma by the pediatric preclinical testing consortium. Pediatric Blood and Cancer, 67(10), Artículo e28606. https://doi.org/10.1002/pbc.28606

Gill, J, Zhang, W, Zhang, Z, Roth, M, Harrison, DJ, Rowshan, S, Erickson, S, Gatto, G, Kurmasheva, R, Houghton, P, Teicher, B, Smith, MA, Kolb, EA & Gorlick, R 2020, 'Dose-response effect of eribulin in preclinical models of osteosarcoma by the pediatric preclinical testing consortium', Pediatric Blood and Cancer, vol. 67, n.º 10, e28606. https://doi.org/10.1002/pbc.28606

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abstract = "The pediatric preclinical testing program previously demonstrated activity of eribulin in osteosarcoma patient-derived xenograft (PDX) models. The phase 2 trial in patients with relapsed osteosarcoma failed to meet response endpoints. Eribulin was evaluated in the original and an expanded set of PDX models and tested at multiple dose levels and schedules to evaluate dose-response. Maximal response was observed at the highest dose, consistent with prior results. The alternative schedule generated similar responses. We demonstrate steep dose-response for eribulin in osteosarcoma PDX models, implying that any deviation from achievement of effective concentrations may have a significant impact on activity.",

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AU - Roth, Michael

AU - Harrison, Douglas J.

AU - Rowshan, Sudie

AU - Erickson, Stephen

AU - Gatto, Gregory

AU - Kurmasheva, Raushan

AU - Houghton, Peter

AU - Teicher, Beverly

AU - Smith, Malcolm A.

AU - Kolb, E. Anders

AU - Gorlick, Richard

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Dose-response effect of eribulin in preclinical models of osteosarcoma by the pediatric preclinical testing consortium

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