Does PTEN loss impair DNA double-strand break repair by homologous recombination?

Clayton R. Hunt; Arun Gupta; Nobuo Horikoshi; Tej K. Pandita

doi:10.1158/1078-0432.CCR-11-3131

Does PTEN loss impair DNA double-strand break repair by homologous recombination?

Clayton R. Hunt
, Arun Gupta
, Nobuo Horikoshi
, Tej K. Pandita

Producción científica: Comment/debate › revisión exhaustiva

29 Citas (Scopus)

Resumen

The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and is not a biomarker for PARP inhibitor sensitivity.

Idioma original	English (US)
Páginas (desde-hasta)	920-922
Número de páginas	3
Publicación	Clinical Cancer Research
Volumen	18
N.º	4
DOI	https://doi.org/10.1158/1078-0432.CCR-11-3131
Estado	Published - feb 15 2012
Publicado de forma externa	Sí

ASJC Scopus subject areas

General Medicine

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10.1158/1078-0432.CCR-11-3131

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@article{b5a26edd6dba471cafb9d5044defd387,

title = "Does PTEN loss impair DNA double-strand break repair by homologous recombination?",

abstract = "The tumor suppressor PTEN is frequently lost in cancer cells, resulting in altered radiation and drug sensitivity. However, the role of PTEN in DNA repair is controversial. Detailed studies in prostate cancer cells now indicate PTEN does not regulate RAD51 expression or homologous recombination and is not a biomarker for PARP inhibitor sensitivity.",

author = "Hunt, \{Clayton R.\} and Arun Gupta and Nobuo Horikoshi and Pandita, \{Tej K.\}",

year = "2012",

month = feb,

day = "15",

doi = "10.1158/1078-0432.CCR-11-3131",

language = "English (US)",

volume = "18",

pages = "920--922",

journal = "Clinical Cancer Research",

issn = "1078-0432",