Do long-lived mutant and calorie-restricted mice share common anti-aging mechanisms? - A pathological point of view

Yuji Ikeno, Christie M. Lew, Lisa A. Cortez, Celeste R. Webb, Shuko Lee, Gene B. Hubbard

Producción científica: Review articlerevisión exhaustiva

17 Citas (Scopus)

Resumen

Rodent models are an invaluable resource for studying the mechanism of mammalian aging. In recent years, the availability of transgenic and knockout mouse models has facilitated the study of potential mechanisms of aging. Since 1996, aging studies with several long-lived mutant mice have been conducted. Studies with the long-lived mutant mice, Ames and Snell dwarf, and growth hormone receptor/binding protein knockout mice, are currently providing important clues regarding the role of the growth hormone/insulin like growth factor-1 axis in the aging process. Interestingly, these studies demonstrate that these long-lived mutant mice have physiological characteristics that are similar to the effects of calorie restriction, which has been the most effective experimental manipulation capable of extending lifespan in various species. However, a question remains to be answered: do these long-lived mutant and calorie-restricted mice extend their lifespan through a common underlying mechanism?

Idioma originalEnglish (US)
Páginas (desde-hasta)163-171
Número de páginas9
PublicaciónAGE
Volumen28
N.º2
DOI
EstadoPublished - jun 2006
Publicado de forma externa

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology

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