@article{1fc279ee6731404c97913ab06e24ebc1,
title = "DNA methylation profiles in African American prostate cancer patients in relation to disease progression",
abstract = "This study examined whether differential DNA methylation is associated with clinical features of more aggressive disease at diagnosis and prostate cancer recurrence in African American men, who are more likely to die from prostate cancer than other populations. Tumor tissues from 76 African Americans diagnosed with prostate cancer who had radical prostatectomy as their primary treatment were profiled for epigenome-wide DNA methylation levels. Long-term follow-up identified 19 patients with prostate cancer recurrence. Twenty-three CpGs were differentially methylated (FDR q ≤ 0.25, mean methylation difference ≥ 0.10) in patients with vs. without recurrence, including CpGs in GCK, CDKL2, PRDM13, and ZFR2. Methylation differences were also observed between men with metastatic-lethal prostate cancer vs. no recurrence (five CpGs), regional vs. local pathological stage (two CpGs), and higher vs. lower tumor aggressiveness (one CpG). These results indicate that differentially methylated CpG sites identified in tumor tissues of African American men may contribute to prostate cancer aggressiveness.",
keywords = "African American, Aggressiveness, DNA methylation, Prostate cancer, Recurrence, Tumor tissue",
author = "Rohina Rubicz and Shanshan Zhao and Milan Geybels and Wright, {Jonathan L.} and Suzanne Kolb and Brandy Klotzle and Marina Bibikova and Dean Troyer and Raymond Lance and Ostrander, {Elaine A.} and Ziding Feng and Fan, {Jian Bing} and Stanford, {Janet L.}",
note = "Funding Information: We thank Drs. Beatrice Knudson and Antonio Hurado-Coll for their assistance with the pathology, and Illumina, Inc. for supplying and performing the DNA methylation and gene expression arrays. Financial support was provided by grants from the National Cancer Institute : R01 CA056678 , R01 CA092579 , K05 CA175147 , and P50 CA097186 ; with additional support from the Fred Hutchinson Cancer Research Center , the Intramural Program of the National Human Genome Research Institute , and the Prostate Cancer Foundation . Milan Geybels is the recipient of a Dutch Cancer Society Fellowship (BUIT 2014–6645). Funding Information: We thank Drs. Beatrice Knudson and Antonio Hurado-Coll for their assistance with the pathology, and Illumina, Inc. for supplying and performing the DNA methylation and gene expression arrays. Financial support was provided by grants from the National Cancer Institute: R01 CA056678, R01 CA092579, K05 CA175147, and P50 CA097186; with additional support from the Fred Hutchinson Cancer Research Center, the Intramural Program of the National Human Genome Research Institute, and the Prostate Cancer Foundation. Milan Geybels is the recipient of a Dutch Cancer Society Fellowship (BUIT 2014?6645). Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",
year = "2019",
month = jan,
doi = "10.1016/j.ygeno.2016.02.004",
language = "English (US)",
volume = "111",
pages = "10--16",
journal = "Genomics",
issn = "0888-7543",
publisher = "Academic Press Inc.",
number = "1",
}