DNA double-strand break processing: The beginning of the end

Steven Raynard, Hengyao Niu, Patrick Sung

Resultado de la investigación: Review articlerevisión exhaustiva

33 Citas (Scopus)

Resumen

Nucleolytic processing of DNA double-strand breaks (DSBs) generates 3′ ssDNA tails that are essential for the assembly of DNA damage checkpoint signaling and DNA repair protein complexes. Genetic studies have provided evidence that multiple nuclease activities are involved in DSB end resection. Three recent studies, including work by Jackson and colleagues (pp. 2767-2772) in the October 15, 2008, issue of Genes & Development, have begun to shed some light on the intricacy of this process.

Idioma originalEnglish (US)
Páginas (desde-hasta)2903-2907
Número de páginas5
PublicaciónGenes and Development
Volumen22
N.º21
DOI
EstadoPublished - nov. 1 2008
Publicado de forma externa

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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