DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: Role of telomere repeat binding factor 2

S. Narayan; A. S. Jaiswal; A. S. Multani; S. Pathak

doi:10.1054/bjoc.2001.2002

DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: Role of telomere repeat binding factor 2

S. Narayan
, A. S. Jaiswal
, A. S. Multani
, S. Pathak

Producción científica: Article › revisión exhaustiva

12 Citas (Scopus)

Resumen

Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G₂/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells.

Idioma original	English (US)
Páginas (desde-hasta)	898-901
Número de páginas	4
Publicación	British Journal of Cancer
Volumen	85
N.º	6
DOI	https://doi.org/10.1054/bjoc.2001.2002
Estado	Published - sept 14 2001
Publicado de forma externa	Sí

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: Role of telomere repeat binding factor 2",

abstract = "Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G2/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells.",

keywords = "Apoptosis, Cell cycle arrest, DNA damage, TRF1, TRF2, Telomere, p53",

author = "S. Narayan and Jaiswal, \{A. S.\} and Multani, \{A. S.\} and S. Pathak",

note = "Funding Information: We are grateful to Dr Bert Vogelstein (The Johns Hopkins Oncology Center, The Johns Hopkins University, Baltimore, MD) for HCT-116(p53–/–) and HCT-116(p53+/+) cell lines, Dr Stratford May for critically reading the manuscript, Dr Virendra Kumar for technical assistance, and Nirupama Gupta for editorial comments. The FACS analysis was performed in the FCC Laboratory of the ICBR of the University of Florida. This work was supported by NIH grants CA77721 (to SN) and RRO4999 (to SP).",

year = "2001",

month = sep,

day = "14",

doi = "10.1054/bjoc.2001.2002",

language = "English (US)",

volume = "85",

pages = "898--901",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

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T1 - DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways

T2 - Role of telomere repeat binding factor 2

AU - Narayan, S.

AU - Jaiswal, A. S.

AU - Multani, A. S.

AU - Pathak, S.

N1 - Funding Information: We are grateful to Dr Bert Vogelstein (The Johns Hopkins Oncology Center, The Johns Hopkins University, Baltimore, MD) for HCT-116(p53–/–) and HCT-116(p53+/+) cell lines, Dr Stratford May for critically reading the manuscript, Dr Virendra Kumar for technical assistance, and Nirupama Gupta for editorial comments. The FACS analysis was performed in the FCC Laboratory of the ICBR of the University of Florida. This work was supported by NIH grants CA77721 (to SN) and RRO4999 (to SP).

PY - 2001/9/14

Y1 - 2001/9/14

N2 - Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G2/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells.

AB - Treatment of colon cancer cells with MNNG causes DNA damage with reduced telomeric signals in a p53-dependent manner, but increased cell cycle arrest in S-G2/M by both p53-dependent and independent mechanisms. Results also indicate that cellular levels of TRF2 may play a critical role in MNNG-induced cell cycle arrest and apoptosis of colon cancer cells.

KW - Apoptosis

KW - Cell cycle arrest

KW - DNA damage

KW - TRF1

KW - TRF2

KW - Telomere

KW - p53

UR - https://www.scopus.com/pages/publications/0035860136

UR - https://www.scopus.com/pages/publications/0035860136#tab=citedBy

U2 - 10.1054/bjoc.2001.2002

DO - 10.1054/bjoc.2001.2002

M3 - Article

C2 - 11556843

AN - SCOPUS:0035860136

SN - 0007-0920

VL - 85

SP - 898

EP - 901

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 6

ER -

DNA damage-induced cell cycle checkpoints involve both p53-dependent and -independent pathways: Role of telomere repeat binding factor 2

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