Distinctions between transgenerational and non-transgenerational epimutations

Producción científica: Review articlerevisión exhaustiva

46 Citas (Scopus)

Resumen

Recent studies have described numerous environmentally-induced disruptions of the epigenome (epimutations) in mammals. While some of these appear to be corrected by normal germline-specific epigenetic reprogramming and are therefore not transmitted transgenerationally, others are not corrected and are transmitted over multiple subsequent generations. The mechanism(s) that distinguish transgenerational and non-transgenerational epimutations have not been delineated. This review examines several potential molecular and developmental distinctions between transgenerational and non-transgenerational epimutations in the context of the likelihood that any of these may or may not contribute to transgenerational inheritance of epimutations.

Idioma originalEnglish (US)
Páginas (desde-hasta)13-23
Número de páginas11
PublicaciónMolecular and Cellular Endocrinology
Volumen398
N.º1-2
DOI
EstadoPublished - dic 1 2014
Publicado de forma externa

ASJC Scopus subject areas

  • Endocrinology
  • Molecular Biology
  • Biochemistry

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