Dinuclear and heptanuclear complexes of copper(II) with 7-azaindole ligand: Synthesis, characterization, magnetic properties, and biological activity

Jacob A. Przyojski; Nicole N. Myers; Hadi D. Arman; Andrey Prosvirin; Kim R. Dunbar; Mohan Natarajan; Manickam Krishnan; Sumathy Mohan; Judith A. Walmsley

doi:10.1016/j.jinorgbio.2013.04.006

Dinuclear and heptanuclear complexes of copper(II) with 7-azaindole ligand: Synthesis, characterization, magnetic properties, and biological activity

Jacob A. Przyojski
, Nicole N. Myers
, Hadi D. Arman
, Andrey Prosvirin
, Kim R. Dunbar
, Mohan Natarajan
, Manickam Krishnan
, Sumathy Mohan
, Judith A. Walmsley

Producción científica: Article › revisión exhaustiva

18 Citas (Scopus)

Resumen

Three new complexes of Cu(II) with 7-azaindole have been synthesized and characterized, a dicopper compound, [Cu(C₇H₅N ₂)₂(H₂O)]₂·2CH₃CN, 1, and two heptacopper compounds [Cu₇(C₇H ₅N₂)₆(μ₃-OH)₆(μ ₂-H₂O)₂(μ₂-CH₃OH) ₄](CH₃COO)₂·2C₇H ₈·6CH₃OH, 2, and [Cu₇(C ₇H₅N₂)₅(CH₃COO) (μ₃-OH)₆(μ₂-H₂O) ₄(μ₂-CH₃OH)₂](CH ₃COO)₂, 4. The structure of 2 is monoclinic and it crystallizes in the P2₁/c space group: a = 13.475(4) Å; b = 12.945(4) Å; c = 23.392(7) Å; β = 91.232(6). It contains a unique Cu₇O₁₂ core in which a central Cu(II) is situated at an inversion center and is bonded to 6 other Cu(II) ions via bridging oxygen atoms from OH^-, H₂O, and CH₃OH groups. Anionic 7-azaindole ligands bridge between adjacent outer Cu(II) ions and all Cu(II) ions have distorted octahedral coordination geometries. Variable temperature magnetic susceptibility measurements revealed the presence of antiferromagnetic exchange interactions between Cu(II) ions which leads to an S = 5/2 ground state at 1.8 K. Cytotoxicity and cell proliferation activities of the Cu compounds using human tongue squamous cell carcinoma and normal cells revealed that the compounds stimulated proliferation in both types of cells.

Idioma original	English (US)
Páginas (desde-hasta)	175-181
Número de páginas	7
Publicación	Journal of Inorganic Biochemistry
Volumen	127
DOI	https://doi.org/10.1016/j.jinorgbio.2013.04.006
Estado	Published - 2013
Publicado de forma externa	Sí

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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10.1016/j.jinorgbio.2013.04.006

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Przyojski, J. A., Myers, N. N., Arman, H. D., Prosvirin, A., Dunbar, K. R., Natarajan, M., Krishnan, M., Mohan, S., & Walmsley, J. A. (2013). Dinuclear and heptanuclear complexes of copper(II) with 7-azaindole ligand: Synthesis, characterization, magnetic properties, and biological activity. Journal of Inorganic Biochemistry, 127, 175-181. https://doi.org/10.1016/j.jinorgbio.2013.04.006

Przyojski, JA, Myers, NN, Arman, HD, Prosvirin, A, Dunbar, KR, Natarajan, M, Krishnan, M, Mohan, S & Walmsley, JA 2013, 'Dinuclear and heptanuclear complexes of copper(II) with 7-azaindole ligand: Synthesis, characterization, magnetic properties, and biological activity', Journal of Inorganic Biochemistry, vol. 127, pp. 175-181. https://doi.org/10.1016/j.jinorgbio.2013.04.006

@article{bd910a54a2b44b5a8a618854aab4de0d,

title = "Dinuclear and heptanuclear complexes of copper(II) with 7-azaindole ligand: Synthesis, characterization, magnetic properties, and biological activity",

abstract = "Three new complexes of Cu(II) with 7-azaindole have been synthesized and characterized, a dicopper compound, [Cu(C7H5N 2)2(H2O)]2·2CH3CN, 1, and two heptacopper compounds [Cu7(C7H 5N2)6(μ3-OH)6(μ 2-H2O)2(μ2-CH3OH) 4](CH3COO)2·2C7H 8·6CH3OH, 2, and [Cu7(C 7H5N2)5(CH3COO) (μ3-OH)6(μ2-H2O) 4(μ2-CH3OH)2](CH 3COO)2, 4. The structure of 2 is monoclinic and it crystallizes in the P21/c space group: a = 13.475(4) {\AA}; b = 12.945(4) {\AA}; c = 23.392(7) {\AA}; β = 91.232(6). It contains a unique Cu7O12 core in which a central Cu(II) is situated at an inversion center and is bonded to 6 other Cu(II) ions via bridging oxygen atoms from OH-, H2O, and CH3OH groups. Anionic 7-azaindole ligands bridge between adjacent outer Cu(II) ions and all Cu(II) ions have distorted octahedral coordination geometries. Variable temperature magnetic susceptibility measurements revealed the presence of antiferromagnetic exchange interactions between Cu(II) ions which leads to an S = 5/2 ground state at 1.8 K. Cytotoxicity and cell proliferation activities of the Cu compounds using human tongue squamous cell carcinoma and normal cells revealed that the compounds stimulated proliferation in both types of cells.",

keywords = "7-Azaindole, Biological activity, Crystal structure, Dinuclear copper, Heptanuclear copper complex, Magnetism",

author = "Przyojski, \{Jacob A.\} and Myers, \{Nicole N.\} and Arman, \{Hadi D.\} and Andrey Prosvirin and Dunbar, \{Kim R.\} and Mohan Natarajan and Manickam Krishnan and Sumathy Mohan and Walmsley, \{Judith A.\}",

note = "Funding Information: This research was supported in part by the Welch Foundation and by the University of Texas at San Antonio to J.A.W., and in part by a grant from the National Aeronautics and Space Administration (No. NNX12AC32G ) to M.N. This article is dedicated in memoriam to Professor Ivano Bertini. ",

year = "2013",

doi = "10.1016/j.jinorgbio.2013.04.006",

language = "English (US)",

volume = "127",

pages = "175--181",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Dinuclear and heptanuclear complexes of copper(II) with 7-azaindole ligand

T2 - Synthesis, characterization, magnetic properties, and biological activity

AU - Przyojski, Jacob A.

AU - Myers, Nicole N.

AU - Arman, Hadi D.

AU - Prosvirin, Andrey

AU - Dunbar, Kim R.

AU - Natarajan, Mohan

AU - Krishnan, Manickam

AU - Mohan, Sumathy

AU - Walmsley, Judith A.

N1 - Funding Information: This research was supported in part by the Welch Foundation and by the University of Texas at San Antonio to J.A.W., and in part by a grant from the National Aeronautics and Space Administration (No. NNX12AC32G ) to M.N. This article is dedicated in memoriam to Professor Ivano Bertini.

PY - 2013

Y1 - 2013

N2 - Three new complexes of Cu(II) with 7-azaindole have been synthesized and characterized, a dicopper compound, [Cu(C7H5N 2)2(H2O)]2·2CH3CN, 1, and two heptacopper compounds [Cu7(C7H 5N2)6(μ3-OH)6(μ 2-H2O)2(μ2-CH3OH) 4](CH3COO)2·2C7H 8·6CH3OH, 2, and [Cu7(C 7H5N2)5(CH3COO) (μ3-OH)6(μ2-H2O) 4(μ2-CH3OH)2](CH 3COO)2, 4. The structure of 2 is monoclinic and it crystallizes in the P21/c space group: a = 13.475(4) Å; b = 12.945(4) Å; c = 23.392(7) Å; β = 91.232(6). It contains a unique Cu7O12 core in which a central Cu(II) is situated at an inversion center and is bonded to 6 other Cu(II) ions via bridging oxygen atoms from OH-, H2O, and CH3OH groups. Anionic 7-azaindole ligands bridge between adjacent outer Cu(II) ions and all Cu(II) ions have distorted octahedral coordination geometries. Variable temperature magnetic susceptibility measurements revealed the presence of antiferromagnetic exchange interactions between Cu(II) ions which leads to an S = 5/2 ground state at 1.8 K. Cytotoxicity and cell proliferation activities of the Cu compounds using human tongue squamous cell carcinoma and normal cells revealed that the compounds stimulated proliferation in both types of cells.

AB - Three new complexes of Cu(II) with 7-azaindole have been synthesized and characterized, a dicopper compound, [Cu(C7H5N 2)2(H2O)]2·2CH3CN, 1, and two heptacopper compounds [Cu7(C7H 5N2)6(μ3-OH)6(μ 2-H2O)2(μ2-CH3OH) 4](CH3COO)2·2C7H 8·6CH3OH, 2, and [Cu7(C 7H5N2)5(CH3COO) (μ3-OH)6(μ2-H2O) 4(μ2-CH3OH)2](CH 3COO)2, 4. The structure of 2 is monoclinic and it crystallizes in the P21/c space group: a = 13.475(4) Å; b = 12.945(4) Å; c = 23.392(7) Å; β = 91.232(6). It contains a unique Cu7O12 core in which a central Cu(II) is situated at an inversion center and is bonded to 6 other Cu(II) ions via bridging oxygen atoms from OH-, H2O, and CH3OH groups. Anionic 7-azaindole ligands bridge between adjacent outer Cu(II) ions and all Cu(II) ions have distorted octahedral coordination geometries. Variable temperature magnetic susceptibility measurements revealed the presence of antiferromagnetic exchange interactions between Cu(II) ions which leads to an S = 5/2 ground state at 1.8 K. Cytotoxicity and cell proliferation activities of the Cu compounds using human tongue squamous cell carcinoma and normal cells revealed that the compounds stimulated proliferation in both types of cells.

KW - 7-Azaindole

KW - Biological activity

KW - Crystal structure

KW - Dinuclear copper

KW - Heptanuclear copper complex

KW - Magnetism

UR - https://www.scopus.com/pages/publications/84884419342

UR - https://www.scopus.com/pages/publications/84884419342#tab=citedBy

U2 - 10.1016/j.jinorgbio.2013.04.006

DO - 10.1016/j.jinorgbio.2013.04.006

M3 - Article

C2 - 23692703

AN - SCOPUS:84884419342

SN - 0162-0134

VL - 127

SP - 175

EP - 181

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

ER -

Dinuclear and heptanuclear complexes of copper(II) with 7-azaindole ligand: Synthesis, characterization, magnetic properties, and biological activity

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