Differential developmental requirement and peripheral regulation for dermal Vγ34 and Vγ36T17 cells in health and inflammation

Yihua Cai, Feng Xue, Chris Fleming, Jie Yang, Chuanlin Ding, Yunfeng Ma, Min Liu, Huang Ge Zhang, Jie Zheng, Na Xiong, Jun Yan

Producción científica: Articlerevisión exhaustiva

122 Citas (Scopus)

Resumen

Dermal IL-17-producing γδT cells have a critical role in skin inflammation. However, their development and peripheral regulation have not been fully elucidated. Here we demonstrate that dermal γδT cells develop from the embryonic thymus and undergo homeostatic proliferation after birth with diversified TCR repertoire. Vγ6T cells are bona fide resident, but precursors of dermal Vγ4T cells may require extrathymic environment for imprinting skin-homing properties. Thymic Vγ6T cells are more competitive than Vγ4 for dermal γδT cell reconstitution and TCRδ -/- mice reconstituted with Vγ6 develop psoriasis-like inflammation after IMQ-application. Although both IL-23 and IL-1γ2 promote Vγ4 and Vγ6 proliferation, Vγ4 are the main source of IL-17 production that requires IL-1 signalling. Mice with deficiency of IL-1RI signalling have significantly decreased skin inflammation. These studies reveal a differential developmental requirement and peripheral regulation for dermal Vγ6 and Vγ4 γδT cells, implying a new mechanism that may be involved in skin inflammation.

Idioma originalEnglish (US)
Número de artículo3986
PublicaciónNature communications
Volumen5
DOI
EstadoPublished - jun 9 2014
Publicado de forma externa

ASJC Scopus subject areas

  • General Chemistry
  • General Biochemistry, Genetics and Molecular Biology
  • General Physics and Astronomy

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