TY - JOUR
T1 - Dietary glucarate-mediated reduction of sensitivity of murine strains to chemical carcinogenesis
AU - Walaszek, Zbigniew
AU - Hanausek-Walaszek, Malgorzata
AU - Webb, Thomas E.
N1 - Funding Information:
Supported in part by CTR, USA grant 1741 to Z.W. and National Cancer Institute DHHS, USA grant CA38125 to T.E.W. The facilities of the O.S.U. Comprehensive Cancer Center were supported by NC1 core grant P-30-CA16058.
PY - 1986/10
Y1 - 1986/10
N2 - Serum β-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL 6 < BALB c, DBA 2, ICR < SENCAR, A He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroids, which in turn reflects the endogenous level of androgens. Dietary calcium d-glucarate, an in vivo β-glucuronidase inhibitor, reduced the steady state level of both β-glucuronidase and 17-ketosteroid excretion in the highly susceptible A He and SENCAR strains to that of strains known to be resistant to chemical carcinogenesis. Sensitivity of the A He strain is significantly reduced by dietary calcium glucarate, which is shown to inhibit DNA binding and the induction of pulmonary adenomas by benzo[a]pyrene.
AB - Serum β-glucuronidase activity is shown to differ quantitatively in the following strains of mice, listed in order of increasing activity: C3H, C57BL 6 < BALB c, DBA 2, ICR < SENCAR, A He. The level of the enzyme in the murine strains is shown to correlate with the urinary excretion of 17-ketosteroids, which in turn reflects the endogenous level of androgens. Dietary calcium d-glucarate, an in vivo β-glucuronidase inhibitor, reduced the steady state level of both β-glucuronidase and 17-ketosteroid excretion in the highly susceptible A He and SENCAR strains to that of strains known to be resistant to chemical carcinogenesis. Sensitivity of the A He strain is significantly reduced by dietary calcium glucarate, which is shown to inhibit DNA binding and the induction of pulmonary adenomas by benzo[a]pyrene.
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U2 - 10.1016/0304-3835(86)90098-4
DO - 10.1016/0304-3835(86)90098-4
M3 - Article
C2 - 3768860
AN - SCOPUS:0022975772
VL - 33
SP - 25
EP - 32
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -