Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species

John W. Bostick, Yetao Wang, Zeli Shen, Yong Ge, Jeffrey Brown, Zong ming E. Chen, Mansour Mohamadzadeh, James G. Fox, Liang Zhou

Resultado de la investigación: Articlerevisión exhaustiva

13 Citas (Scopus)


Intestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identified opposing effects on ILCs by two Helicobacter species, Helicobacter apodemus and Helicobacter typhlonius, isolated from immunocompromised mice. We demonstrated that the introduction of both Helicobacter species activated ILCs and induced gut inflammation; however, these Helicobacter species negatively regulated RORγt+ group 3 ILCs (ILC3s), especially T-bet+ ILC3s, and diminished their proliferative capacity. Thus, these findings underscore a previously unknown dichotomous regulation of ILC3s by Helicobacter species, and may serve as a model for further investigations to elucidate the host–microbe interactions that critically sustain the maintenance of intestinal ILC3s.

Idioma originalEnglish (US)
Páginas (desde-hasta)24760-24769
Número de páginas10
PublicaciónProceedings of the National Academy of Sciences of the United States of America
EstadoPublished - dic 3 2019
Publicado de forma externa

ASJC Scopus subject areas

  • General


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