Diaphragm-like strictures of the ileum associated with NSAID use: A rare complication

Gregory A. Abrahamian, Clinton D. Polhamus, Peter Muskat, Richard E. Karulf

Producción científica: Articlerevisión exhaustiva

18 Citas (Scopus)


Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed for many conditions including arthritis. A rare complication of their use is diaphragm-like strictures of the small and large intestines. A 65-year-old woman with a 12-year history of arthritis came to us with a 35-pound weight loss and anorexia. She had been taking piroxicam for 3 years. Evaluation including enteroclysis revealed multiple mid-ileal diaphragm-like strictures and proximal small bowel dilatation. The symptoms persisted despite discontinuance of the drug. Abdominal exploration with intraoperative enteroscopy revealed five ileal strictures within a short segment of bowel. Resection was done and completion enteroscopy showed no other strictures. The patient recovered uneventfully and had full resolution of the symptoms. We discuss the difficulties in diagnosis and management of this drug complication and briefly review the literature.

Idioma originalEnglish (US)
Páginas (desde-hasta)395-397
Número de páginas3
PublicaciónSouthern medical journal
EstadoPublished - abr 1998
Publicado de forma externa

ASJC Scopus subject areas

  • General Medicine


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