Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

Mark P. Goldberg; Phuong Chi Pham; Dennis W. Choi

doi:10.1016/0304-3940(87)90486-1

Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

Mark P. Goldberg, Phuong Chi Pham, Dennis W. Choi

Producción científica: Article › revisión exhaustiva

81 Citas (Scopus)

Resumen

The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.

Idioma original	English (US)
Páginas (desde-hasta)	11-15
Número de páginas	5
Publicación	Neuroscience Letters
Volumen	80
N.º	1
DOI	https://doi.org/10.1016/0304-3940(87)90486-1
Estado	Published - sept 11 1987
Publicado de forma externa	Sí

ASJC Scopus subject areas

General Neuroscience

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title = "Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture",

abstract = "The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.",

keywords = "Cell culture, Cerebral cortex, Cerebral ischemia, Glutamate, Hypoxia, N-Methyl-d-aspartate, Opioid",

author = "Goldberg, {Mark P.} and Pham, {Phuong Chi} and Choi, {Dennis W.}",

note = "Funding Information: We thank Professor A. Goldstein and Dr. C. Weitz for helpful discussions, and Dr. Sorter at Hoffmann-La Roche for the kind gift of DX and LV. This research was supported by grants from the Wills Foundation and the Hereditary Disease Foundation. D.W.C. is a Hartford Foundation Fellow.",

year = "1987",

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doi = "10.1016/0304-3940(87)90486-1",

language = "English (US)",

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T1 - Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

AU - Goldberg, Mark P.

AU - Pham, Phuong Chi

AU - Choi, Dennis W.

N1 - Funding Information: We thank Professor A. Goldstein and Dr. C. Weitz for helpful discussions, and Dr. Sorter at Hoffmann-La Roche for the kind gift of DX and LV. This research was supported by grants from the Wills Foundation and the Hereditary Disease Foundation. D.W.C. is a Hartford Foundation Fellow.

PY - 1987/9/11

Y1 - 1987/9/11

N2 - The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.

AB - The dextrorotatory opioid derivatives, dextrorphan and dextromethorphan, can attenuate hypoxic injury in cortical cell cultures. This effect is concentration-dependent in the micromolar range, and not strongly stereospecific, as it can also be demonstrated with the levorotatory enantiomer of dextrorphan, levorphanol. The possibility that these clinically available compounds may have therapeutic utility in hypoxic or ischemic encephalopathy warrants further investigation.

KW - Cell culture

KW - Cerebral cortex

KW - Cerebral ischemia

KW - Glutamate

KW - Hypoxia

KW - N-Methyl-d-aspartate

KW - Opioid

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Dextrorphan and dextromethorphan attenuate hypoxic injury in neuronal culture

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