Developmental endothelial locus-1 prevents development of peritoneal adhesions in mice

Yan Fu, Jiaywei Tsauo, Yucheng Sun, Zhe Wang, Kun Yung Kim, Seung Hwan Lee, Dong Young Kim, Feifeng Jing, Dahae Lim, Ho Young Song, Hoon Hyun, Eun Young Choi

Resultado de la investigación: Articlerevisión exhaustiva

6 Citas (Scopus)

Resumen

Postoperative peritoneal adhesions, fibrous bands formed in the peritoneal cavity following surgery, represent a common, challenging and costly problem faced by surgeons and patients, for which effective therapeutic options are lacking. Since aberrant inflammation is one of the key mechanisms underlying peritoneal adhesion formation, here we set out to study the role of developmental endothelial locus-1 (Del-1), which has been recently identified as an endogenous inhibitor of inflammation, in the formation of postoperative peritoneal adhesions using a mouse model of peritoneal adhesions induced by ischemic buttons. Del-1-deficient mice had a higher incidence of adhesions, and their adhesions had higher quality and tenacity scores. Del-1 deficiency also led to enhanced inflammation mediators and collagen production. Finally, Del-1 supplementation decreased the incidence and severity of postoperative peritoneal adhesions. Taken together, these results indicate a protective role for Del-1 in postoperative peritoneal adhesion formation.

Idioma originalEnglish (US)
Páginas (desde-hasta)783-789
Número de páginas7
PublicaciónBiochemical and Biophysical Research Communications
Volumen500
N.º3
DOI
EstadoPublished - jun. 7 2018
Publicado de forma externa

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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