@article{2ad6a21a9c1d436889e28f7fe046d826,
title = "Development of caspofungin resistance following prolonged therapy for invasive candidiasis secondary to Candida glabrata infection",
abstract = "We report a case of Candida glabrata invasive candidiasis that developed reduced susceptibility to caspofungin during prolonged therapy. Pre- and posttreatment isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed an F659V substitution within the FKS2 region of the glucan synthase complex.",
author = "Thompson, \{George R.\} and Wiederhold, \{Nathan P.\} and Vallor, \{Ana C.\} and Villareal, \{Nyria C.\} and Lewis, \{James S.\} and Patterson, \{Thomas F.\}",
note = "Funding Information: The author would like to acknowledge research support from the Australian Research Council through Discovery Grant programmes DP120101237 and DP150103294. He is also grateful for the support received during an extended visit to the Institute forAstronomy, University of Edinburgh during which this paper was largely written. Thanks also to Ken Freeman, Russell Cannon and Elizabeth Maunder who conducted the 2010 December observations, and to Andrew Cole for providing a copy of the line profile fitting code (whose heritage can be traced back to that of Armandroff \& Da Costa 'plus ?a change, plus c'est la m?me chose'). This research has made use of theWEBDA data base, operated at the Institute for Astronomy of the University of Vienna, and of the VizieR catalogue access tool, CDS, Strasbourg, France. The original description of the VizieR service was published in A \& AS, 143, 23.",
year = "2008",
month = oct,
doi = "10.1128/AAC.00473-08",
language = "English (US)",
volume = "52",
pages = "3783--3785",
journal = "Antimicrobial agents and chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "10",
}