Development and selection of γδ T cells

Na Xiong, David H. Raulet

Producción científica: Review articlerevisión exhaustiva

143 Citas (Scopus)

Resumen

Two main lineages of T cells develop in the thymus: those that express the αβ T-cell receptor (TCR) and those that express the γδ TCR. Whereas the development, selection, and peripheral localization of newly differentiated αβ T cells are understood in some detail, these processes are less well characterized in γδ T cells. This review describes research carried out in this laboratory and others, which addresses several key aspects of γδ T-cell development, including the decision of precursor cells to differentiate into the γδ versus αβ lineage, the ordered differentiation over the course of ontogeny of functional γδ T-cell subsets expressing distinct TCR structures, programming of ordered Vγ gene rearrangement in the thymus, including a molecular switch that ensures appropriate Vγ rearrangements at the appropriate stage of development, positive selection in the thymus of γδ T cells destined for the epidermis, and the acquisition by developing γδ T cells of cues that determine their correct localization in the periphery. This research suggests a coordination of molecularly programmed events and cellular selection, which enables specialization of the thymus for production of distinct T-cell subsets at different stages of development.

Idioma originalEnglish (US)
Páginas (desde-hasta)15-31
Número de páginas17
PublicaciónImmunological Reviews
Volumen215
N.º1
DOI
EstadoPublished - feb 2007
Publicado de forma externa

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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