Determination of SCH 39304 by megabore capillary gas-liquid chromatography

Jack E. Wallace, Parviz Mojaverian, Ching C. Lin, Hong K. Kim, Steven C. Harris, Thomas J.H. Chen, Michael G. Rinaldi

Resultado de la investigación: Articlerevisión exhaustiva


A gas-liquid chromatographic procedure for determination of SCH 39304 at low nanogram concentrations in serum, cerebrospinal fluid, and urine is presented. The methodology combines a high selectivity and sensitivity nitrogen-specific detector, a gas chromatograph equipped with a capillary "megabore" column, and an internal standard that is very similar in chemical structure to the drug being assayed. This method is suitable for both pharmacokinetic studies as well as for monitoring drug levels in patients receiving SCH 39304 for antifungal treatment.

Idioma originalEnglish (US)
Páginas (desde-hasta)118-121
Número de páginas4
PublicaciónJournal of Analytical Toxicology
EstadoPublished - mar 1994
Publicado de forma externa

ASJC Scopus subject areas

  • Analytical Chemistry
  • Environmental Chemistry
  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety


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