Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma

Teresa L. Johnson-Pais; Maggie J. Nellissery; Donald G. Ammerman; Dharmini Pathmanathan; Pardeep Bhatia; Carolyn L. Buller; Robin J. Leach; Marc F. Hansen

doi:10.1002/ijc.11070

Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma

Teresa L. Johnson-Pais, Maggie J. Nellissery, Donald G. Ammerman, Dharmini Pathmanathan, Pardeep Bhatia, Carolyn L. Buller, Robin J. Leach, Marc F. Hansen

Producción científica: Article › revisión exhaustiva

20 Citas (Scopus)

Resumen

Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.

Idioma original	English (US)
Páginas (desde-hasta)	285-288
Número de páginas	4
Publicación	International Journal of Cancer
Volumen	105
N.º	2
DOI	https://doi.org/10.1002/ijc.11070
Estado	Published - jun 10 2003

ASJC Scopus subject areas

Oncology
Cancer Research

Acceder al documento

10.1002/ijc.11070

Otros archivos y enlaces

Citar esto

@article{ca3787040b6641639b548a87e2dc859f,

title = "Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma",

abstract = "Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.",

keywords = "Chromosome 18, Loss of heterozygosity, Osteosarcoma, Tumor-suppressor gene",

author = "Johnson-Pais, {Teresa L.} and Nellissery, {Maggie J.} and Ammerman, {Donald G.} and Dharmini Pathmanathan and Pardeep Bhatia and Buller, {Carolyn L.} and Leach, {Robin J.} and Hansen, {Marc F.}",

year = "2003",

month = jun,

day = "10",

doi = "10.1002/ijc.11070",

language = "English (US)",

volume = "105",

pages = "285--288",

journal = "International Journal of Cancer",

issn = "0020-7136",

publisher = "John Wiley and Sons Inc.",

number = "2",

}

TY - JOUR

T1 - Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma

AU - Johnson-Pais, Teresa L.

AU - Nellissery, Maggie J.

AU - Ammerman, Donald G.

AU - Pathmanathan, Dharmini

AU - Bhatia, Pardeep

AU - Buller, Carolyn L.

AU - Leach, Robin J.

AU - Hansen, Marc F.

PY - 2003/6/10

Y1 - 2003/6/10

N2 - Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.

AB - Previous analysis of tumor-specific constitutional LOH had identified a putative tumor-suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2.

KW - Chromosome 18

KW - Loss of heterozygosity

KW - Osteosarcoma

KW - Tumor-suppressor gene

UR - http://www.scopus.com/inward/record.url?scp=0242432391&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242432391&partnerID=8YFLogxK

U2 - 10.1002/ijc.11070

DO - 10.1002/ijc.11070

M3 - Article

C2 - 12673693

AN - SCOPUS:0242432391

SN - 0020-7136

VL - 105

SP - 285

EP - 288

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 2

ER -

Determination of a minimal region of loss of heterozygosity on chromosome 18Q21.33 in osteosarcoma

Resumen

ASJC Scopus subject areas

Acceder al documento

Otros archivos y enlaces

Huella

Citar esto