Determinants of TCDD half-life in veterans of operation ranch hand

William H. Wolfe; Joel E. Michalek; Judson C. Miner; James L. Pirkle; Samuel P. Caudill; Donald G. Patterson; Larry L. Needham

doi:10.1080/15287399409531858

Determinants of TCDD half-life in veterans of operation ranch hand

William H. Wolfe, Joel E. Michalek, Judson C. Miner, James L. Pirkle, Samuel P. Caudill, Donald G. Patterson, Larry L. Needham

Producción científica: Article › revisión exhaustiva

93 Citas (Scopus)

Resumen

The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) changed significantly with body fat and age in 337 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. Using paired TCDD measurements derived from serum collected in 1982 and in 1987, we investigated how TCDD half-life varied with percent body fat (PBF), relative changes in PBF, and age. We found that halflife increased significantly with increasing PBF and decreased significantly with increasing relative change in PBF and with age. The median observed half-life of TCDD for these 337 veterans is 11.3 yr with a nonparametric 95% confidence interval of 10.0-14.1 yr.

Idioma original	English (US)
Páginas (desde-hasta)	481-488
Número de páginas	8
Publicación	Journal of toxicology and environmental health
Volumen	41
N.º	4
DOI	https://doi.org/10.1080/15287399409531858
Estado	Published - abr 1994

ASJC Scopus subject areas

Pollution
Toxicology

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title = "Determinants of TCDD half-life in veterans of operation ranch hand",

abstract = "The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) changed significantly with body fat and age in 337 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. Using paired TCDD measurements derived from serum collected in 1982 and in 1987, we investigated how TCDD half-life varied with percent body fat (PBF), relative changes in PBF, and age. We found that halflife increased significantly with increasing PBF and decreased significantly with increasing relative change in PBF and with age. The median observed half-life of TCDD for these 337 veterans is 11.3 yr with a nonparametric 95% confidence interval of 10.0-14.1 yr.",

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T1 - Determinants of TCDD half-life in veterans of operation ranch hand

AU - Wolfe, William H.

AU - Michalek, Joel E.

AU - Miner, Judson C.

AU - Pirkle, James L.

AU - Caudill, Samuel P.

AU - Patterson, Donald G.

AU - Needham, Larry L.

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AB - The half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) changed significantly with body fat and age in 337 members of Operation Ranch Hand, the Air Force unit responsible for the aerial spraying of Agent Orange in Vietnam. Using paired TCDD measurements derived from serum collected in 1982 and in 1987, we investigated how TCDD half-life varied with percent body fat (PBF), relative changes in PBF, and age. We found that halflife increased significantly with increasing PBF and decreased significantly with increasing relative change in PBF and with age. The median observed half-life of TCDD for these 337 veterans is 11.3 yr with a nonparametric 95% confidence interval of 10.0-14.1 yr.

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Determinants of TCDD half-life in veterans of operation ranch hand

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