Detection and noninvasive diagnostics of breast cancer with two-color laser optoacoustic imaging system

Sergey Ermilov, Alan Stein, Andre Conjusteau, Reda Gharieb, Ron Lacewell, Tom Miller, Scott Thompson, Pamela Otto, Barbara M Mccorvey, Tuenchit Khamapirad, Morton Leonard, Alexander Oraevsky

Producción científica: Conference contribution

34 Citas (Scopus)

Resumen

We have designed, fabricated and tested a new laser optoacoustic imaging system (LOIS-64/16) for quantitative optoacoustic tomography of breast cancer. The system was designed to create a single slice of an optoacoustic image of the breast with 64 ultrawide band acoustic transducers. Other 16 transducers on the back of the acoustic probe were used to reconstruct the light distribution inside the breast. The system resolution was at least 0.5 mm for high-aspect-ratio objects. Maximum system sensitivity was 4.8 mV/Pa and the RMS noise of 3.1 mV, which allowed imaging of small (less than 1 cm) tumors at depths over 3 cm. The directivity of the optoacoustic transducers used in LOIS-64/16 assured that the signal detection was better than 70% of the maximum for about 75% of the imaging slice and reduced quickly for signals coming from out of the imaging slice. Implemented signal processing allowed significant reduction of the low-frequency acoustic noise and localizing the small OA signals. The system was able to differentiate phantoms mimicking tumors and malformations visualized in clinics based on the contrast and morphology of their images obtained at 1064 nm and 757 nm.

Idioma originalEnglish (US)
Título de la publicación alojadaPhotons Plus Ultrasound
Subtítulo de la publicación alojadaImaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
DOI
EstadoPublished - 2007
EventoPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics - San Jose, CA, United States
Duración: ene 21 2007ene 24 2007

Serie de la publicación

NombreProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volumen6437
ISSN (versión impresa)1605-7422

Other

OtherPhotons Plus Ultrasound: Imaging and Sensing 2007: The Eighth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acousto-optics
País/TerritorioUnited States
CiudadSan Jose, CA
Período1/21/071/24/07

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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