Design and synthesis of indol-2-one derivatives as potential RET inhibitors

Zhenzhu Li, Kai Sun, Yuanhong Xu, Fuli Zhu, Zhenyu Mao, Yang Wang, Yaxia Yuan, Ting Qiu, Xiabin Chen, Lei Ma

Producción científica: Articlerevisión exhaustiva


We synthesized and assessed five series of indol-2-one derivatives for their potential as RET kinase inhibitors. Notably, compounds B3, B6, D1, D2, D3, and D5 demonstrated significant inhibitory activity. Among these, D5 exhibited the best activity of inhibiting RET kinase, which provided reference for the subsequent development of RET kinase inhibitors as anti-thyroid cancer chemical.

Idioma originalEnglish (US)
Número de artículo129538
PublicaciónBioorganic and Medicinal Chemistry Letters
EstadoPublished - dic 15 2023

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry


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