Demystifying Cell Cycle Arrest by HIV-1 Vif

Daniel J. Salamango; Reuben S. Harris

doi:10.1016/j.tim.2021.01.001

Demystifying Cell Cycle Arrest by HIV-1 Vif

Daniel J. Salamango, Reuben S. Harris

Producción científica: Short survey › revisión exhaustiva

9 Citas (Scopus)

Resumen

Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.

Idioma original	English (US)
Páginas (desde-hasta)	381-384
Número de páginas	4
Publicación	Trends in Microbiology
Volumen	29
N.º	5
DOI	https://doi.org/10.1016/j.tim.2021.01.001
Estado	Published - may 2021
Publicado de forma externa	Sí

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Virology
Microbiology

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10.1016/j.tim.2021.01.001

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title = "Demystifying Cell Cycle Arrest by HIV-1 Vif",

abstract = "Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.",

keywords = "G2/M cell cycle arrest, HIV-1, PPP2R5, Vif, host–pathogen interaction",

author = "Salamango, {Daniel J.} and Harris, {Reuben S.}",

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AU - Salamango, Daniel J.

AU - Harris, Reuben S.

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AB - Although APOBEC3 degradation is the canonical function of HIV-1 Vif, this viral protein also induces potent cell cycle arrest through a newly defined mechanism. Here, we review recent advances in this area and propose that the scope of this activity may go beyond subversion of the host cell cycle.

KW - G2/M cell cycle arrest

KW - HIV-1

KW - PPP2R5

KW - Vif

KW - host–pathogen interaction

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Demystifying Cell Cycle Arrest by HIV-1 Vif

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ASJC Scopus subject areas

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