TY - JOUR
T1 - Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer
AU - Nair, Hareesh B.
AU - Sung, Bokyung
AU - Yadav, Vivek R.
AU - Kannappan, Ramaswamy
AU - Chaturvedi, Madan M.
AU - Aggarwal, Bharat B.
N1 - Funding Information:
We would like to thank Markeda Wade and Stephanie Deming for carefully editing the manuscript and providing valuable comments. We also thank Dr. Chitra Sundaram for assisting with references. This work was supported by MD Anderson's Cancer Center Support Grant from the National Institutes of Health ( NIH CA-16 672 ), a program project grant from the National Institutes of Health ( NIH CA-124787-01A2 ), and a grant from the Center for Targeted Therapy at The University of Texas MD Anderson Cancer Center, where Dr. Aggarwal is the Ransom Horne, Jr., Professor of Cancer Research.
PY - 2010/12/15
Y1 - 2010/12/15
N2 - Extensive research within the last two decades has revealed that most chronic illnesses, including cancer, diabetes, and cardiovascular and pulmonary diseases, are mediated through chronic inflammation. Thus, suppressing chronic inflammation has the potential to delay, prevent, and even treat various chronic diseases, including cancer. Various nutraceuticals from fruits, vegetables, vitamins, spices, legumes, and traditional Chinese and Ayurvedic medicine have been shown to safely suppress proinflammatory pathways; however, their low bioavailability in vivo limits their use in preventing and treating cancer. We describe here the potential of nanotechnology to fill this gap. Several nutraceuticals, including curcumin, green tea polyphenols, coenzyme Q, quercetin, thymoquinone and others, have been packaged as nanoparticles and proven to be useful in " nanochemoprevention" and " nano-chemotherapy"
AB - Extensive research within the last two decades has revealed that most chronic illnesses, including cancer, diabetes, and cardiovascular and pulmonary diseases, are mediated through chronic inflammation. Thus, suppressing chronic inflammation has the potential to delay, prevent, and even treat various chronic diseases, including cancer. Various nutraceuticals from fruits, vegetables, vitamins, spices, legumes, and traditional Chinese and Ayurvedic medicine have been shown to safely suppress proinflammatory pathways; however, their low bioavailability in vivo limits their use in preventing and treating cancer. We describe here the potential of nanotechnology to fill this gap. Several nutraceuticals, including curcumin, green tea polyphenols, coenzyme Q, quercetin, thymoquinone and others, have been packaged as nanoparticles and proven to be useful in " nanochemoprevention" and " nano-chemotherapy"
KW - Cancer
KW - Curcumin
KW - Diabetes
KW - Inflammation
KW - NF-κB
KW - Nanotechnology
KW - Nutraceuticals
UR - http://www.scopus.com/inward/record.url?scp=78049442013&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049442013&partnerID=8YFLogxK
U2 - 10.1016/j.bcp.2010.07.021
DO - 10.1016/j.bcp.2010.07.021
M3 - Review article
C2 - 20654584
AN - SCOPUS:78049442013
SN - 0006-2952
VL - 80
SP - 1833
EP - 1843
JO - Biochemical Pharmacology
JF - Biochemical Pharmacology
IS - 12
ER -