TY - JOUR
T1 - Definition of and mechanism for opioid-induced sedation
AU - Young-McCaughan, Stacey
AU - Miaskowski, Christine
N1 - Funding Information:
Supported by the Oncology Nursing Foundation, the Department of Defense TriService Nursing Research Program (N96-023) at the Uniformed Services University of the Health Sciences, the University of California San Francisco Center for Symptom Management (NINR P30 NR03927), and the University of California San Francisco Century Club.
PY - 2001
Y1 - 2001
N2 - Although sedation is acknowledged to be one of the most common side effects of opioid analgesics, the mechanisms and characteristics of this phenomenon remain elusive, and research in this area is extremely limited. This report integrates research findings on the mechanism of action of opioids with research findings on the phenomenon of consciousness to develop a model of how opioids may act in the central nervous system to produce sedation. Based on this integration, a definition of opioid-induced sedation is proposed to encourage dialogue and research on this perplexing and clinically significant phenomenon.
AB - Although sedation is acknowledged to be one of the most common side effects of opioid analgesics, the mechanisms and characteristics of this phenomenon remain elusive, and research in this area is extremely limited. This report integrates research findings on the mechanism of action of opioids with research findings on the phenomenon of consciousness to develop a model of how opioids may act in the central nervous system to produce sedation. Based on this integration, a definition of opioid-induced sedation is proposed to encourage dialogue and research on this perplexing and clinically significant phenomenon.
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U2 - 10.1053/jpmn.2001.25012
DO - 10.1053/jpmn.2001.25012
M3 - Article
C2 - 11710090
AN - SCOPUS:0035160426
SN - 1524-9042
VL - 2
SP - 84
EP - 97
JO - Pain Management Nursing
JF - Pain Management Nursing
IS - 3
ER -