TY - JOUR
T1 - Data on genetic associations of carotid atherosclerosis markers in Mexican American and European American rheumatoid arthritis subjects
AU - Arya, Rector
AU - Escalante, Agustin
AU - Farook, Vidya S.
AU - Restrepo, Jose F.
AU - Battafarano, Daniel F.
AU - Almeida, Marcio
AU - Kos, Mark Z.
AU - Fourcaudot, Marcel J.
AU - Mummidi, Srinivas
AU - Kumar, Satish
AU - Curran, Joanne E.
AU - Jenkinson, Christopher P.
AU - Blangero, John
AU - Duggirala, Ravindranath
AU - del Rincon, Inmaculada
N1 - Funding Information:
We thank the participants of the ORALE study. This work was supported by grants from the US National Institutes of Health ( R01-HL-085742 , R01-HD-037151 , and UL1-RR-25767 ).
Publisher Copyright:
© 2018 The Authors
PY - 2018/4
Y1 - 2018/4
N2 - Carotid Intima-media thickness (CIMT) and plaque are well established markers of subclinical atherosclerosis and are widely used for identifying subclinical atherosclerotic disease. We performed association analyses using Metabochip array to identify genetic variants that influence variation in CIMT and plaque, measured using B-mode ultrasonography, in rheumatoid arthritis (RA) patients. Data on genetic associations of common variants associated with both CIMT and plaque in RA subjects involving Mexican Americans (MA) and European Americans (EA) populations are presented in this article. Strong associations were observed after adjusting for covariate effects including baseline clinical characteristics and statin use. Susceptibility loci and genes and/or nearest genes associated with CIMT in MAs and EAs with RA are presented. In addition, common susceptibility loci influencing CIMT and plaque in both MAs and EAs have been presented. Polygenic Risk Score (PRS) plots showing complementary evidence for the observed CIMT and plaque association signals are also shown in this article. For further interpretation and details, please see the research article titled “A Genetic Association Study of Carotid Intima-Media Thickness (CIMT) and Plaque in Mexican Americans and European Americans with Rheumatoid Arthritis” which is being published in Atherosclerosis (Arya et al., 2018) [1].(Arya et al., in press) Thus, common variants in several genes exhibited significant associations with CIMT and plaque in both MAs and EAs as presented in this article. These findings may help understand the genetic architecture of subclinical atherosclerosis in RA populations.
AB - Carotid Intima-media thickness (CIMT) and plaque are well established markers of subclinical atherosclerosis and are widely used for identifying subclinical atherosclerotic disease. We performed association analyses using Metabochip array to identify genetic variants that influence variation in CIMT and plaque, measured using B-mode ultrasonography, in rheumatoid arthritis (RA) patients. Data on genetic associations of common variants associated with both CIMT and plaque in RA subjects involving Mexican Americans (MA) and European Americans (EA) populations are presented in this article. Strong associations were observed after adjusting for covariate effects including baseline clinical characteristics and statin use. Susceptibility loci and genes and/or nearest genes associated with CIMT in MAs and EAs with RA are presented. In addition, common susceptibility loci influencing CIMT and plaque in both MAs and EAs have been presented. Polygenic Risk Score (PRS) plots showing complementary evidence for the observed CIMT and plaque association signals are also shown in this article. For further interpretation and details, please see the research article titled “A Genetic Association Study of Carotid Intima-Media Thickness (CIMT) and Plaque in Mexican Americans and European Americans with Rheumatoid Arthritis” which is being published in Atherosclerosis (Arya et al., 2018) [1].(Arya et al., in press) Thus, common variants in several genes exhibited significant associations with CIMT and plaque in both MAs and EAs as presented in this article. These findings may help understand the genetic architecture of subclinical atherosclerosis in RA populations.
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U2 - 10.1016/j.dib.2018.02.006
DO - 10.1016/j.dib.2018.02.006
M3 - Article
AN - SCOPUS:85042375454
SN - 2352-3409
VL - 17
SP - 820
EP - 829
JO - Data in Brief
JF - Data in Brief
ER -