Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil

C. A. Gauthier, J. R. Bagley, L. L. Brockunier, Charles P. France

Producción científica: Articlerevisión exhaustiva

3 Citas (Scopus)

Resumen

The fentanyl derivative mirfentanil has a novel set of behavioral effects in non-humans including low-efficacy opioid actions and non-opioid antinociceptive actions. This study evaluated the rate decreasing effects of mirfentanil, morphine, naltrexone and ketamine in pigeons both prior to and during a period of chronic treatment with mirfentanil (3.2-17.8 mg/kg/day). Daily treatment with mirfentanil did not modify the rate-decreasing effects of mirfentanil or ketamine; however, daily treatment decreased sensitivity to the rate decreasing effects of morphine and increased sensitivity to naltrexone. These results demonstrate a lack of tolerance to an apparently non-opioid action (rate-decreasing effect) of mirfentanil, which might predict a lack of tolerance to the non-opioid antinociceptive actions of this compound. These results further indicate that cross-tolerance (to morphine) and dependence (increased sensitivity to naltrexone) can occur in the absence of tolerance (to mirfentanil).

Idioma originalEnglish (US)
Páginas (desde-hasta)543-547
Número de páginas5
PublicaciónBehavioural pharmacology
Volumen10
N.º5
DOI
EstadoPublished - 1999
Publicado de forma externa

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology

Huella

Profundice en los temas de investigación de 'Daily mirfentanil induces (cross-) tolerance to the rate-decreasing effects of morphine and not mirfentanil'. En conjunto forman una huella única.

Citar esto