DAI Another Way: Necroptotic Control of Viral Infection

Jason W. Upton, William J. Kaiser

Resultado de la investigación: Comment/debaterevisión exhaustiva

18 Citas (Scopus)

Resumen

Interrogation of murine cytomegalovirus (MCMV)-encoded cell-death suppressors revealed that necroptosis functions as a trap door to eliminate virally infected cells. This crucial host defense pathway is orchestrated by the sensing of infection by DAI/ZBP-1, engagement of the kinase RIPK3, and subsequent membrane permeablization by the pseudokinase MLKL.

Idioma originalEnglish (US)
Páginas (desde-hasta)290-293
Número de páginas4
PublicaciónCell Host and Microbe
Volumen21
N.º3
DOI
EstadoPublished - mar 8 2017

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Virology

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