TY - JOUR
T1 - Cytotoxic activity of the titanium alkoxide (OPy) 2Ti(4AP) 2 against cancer colony forming cells
AU - Williamson, Elizabeth A.
AU - Boyle, Timothy J.
AU - Raymond, Rebecca
AU - Farrington, Jacqueline
AU - Verschraegen, Claire
AU - Shaheen, Montaser
AU - Hromas, Robert
N1 - Funding Information:
Acknowledgements RH was supported by LLS 7388-06, NIH CA139429, NIH CA100862, NIH CA140442, and NIH HL075783. The authors also thank the U.S. Department of Energy, Office of Basic Energy Sciences, Division of Materials Sciences under Contract DE-AC04-94AL85000. Sandia is a multiprogramming laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy
PY - 2012/2
Y1 - 2012/2
N2 - A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines using colony formation assays. One compound, (OPy) 2Ti(4AP) 2, where OPy is NC 5H 5CH 2O-, and 4AP is 4-aminophenoxide (-OC 6H 5(NH 2)-4), demonstrated increased cytotoxicity in breast, colon, and pancreatic cancer cell lines at 100 nanomolar levels with only short exposures. Further, (OPy) 2Ti(4AP) 2 had activity in colon and pancreatic cancer cell lines that are usually resistant to chemotherapy. This demonstrates that these novel titanium compounds may have a role in anti-cancer therapy, similar to platinum-based compounds, and the (OPy) 2Ti(4AP) 2 compound specifically deserves further investigation as an anticancer agent in chemo-resistant solid tumors.
AB - A novel family of titanium alkoxides with two stable pyridinemethoxide moieties bound to a titanium metal center were synthesized and tested for cytotoxic activity on a variety of cancer cell lines using colony formation assays. One compound, (OPy) 2Ti(4AP) 2, where OPy is NC 5H 5CH 2O-, and 4AP is 4-aminophenoxide (-OC 6H 5(NH 2)-4), demonstrated increased cytotoxicity in breast, colon, and pancreatic cancer cell lines at 100 nanomolar levels with only short exposures. Further, (OPy) 2Ti(4AP) 2 had activity in colon and pancreatic cancer cell lines that are usually resistant to chemotherapy. This demonstrates that these novel titanium compounds may have a role in anti-cancer therapy, similar to platinum-based compounds, and the (OPy) 2Ti(4AP) 2 compound specifically deserves further investigation as an anticancer agent in chemo-resistant solid tumors.
KW - Colon cancer
KW - Colony forming cell
KW - Lung cancer
KW - Pancreatic cancer
KW - Titanium alkoxides
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U2 - 10.1007/s10637-010-9530-3
DO - 10.1007/s10637-010-9530-3
M3 - Article
C2 - 20820908
AN - SCOPUS:84856536312
SN - 0167-6997
VL - 30
SP - 114
EP - 120
JO - Investigational New Drugs
JF - Investigational New Drugs
IS - 1
ER -