Cutting edge: Intrinsic programming of thymic γδT cells for specific peripheral tissue localization

Yan Jin, Mingcan Xia, Christina M. Saylor, Kavitha Narayan, Joonsoo Kang, David L. Wiest, Yanming Wang, Na Xiong

Producción científica: Articlerevisión exhaustiva

42 Citas (Scopus)

Resumen

Various innate-like T cell subsets preferentially reside in specific epithelial tissues as the first line of defense. However, mechanisms regulating their tissue-specific development are poorly understood. Using the prototypical skin intraepithelial γδT cells (sIELs) as a model, we show in this study that a TCR-mediated selection plays an important role in promoting acquisition of a specific skin-homing property by fetal thymic sIEL precursors for their epidermal location, and the skinhoming potential is intrinsically programmed even before the selection. In addition, once localized in the skin, the sIEL precursors develop into sIELs without the requirement of further TCR-ligand interaction. These studies reveal that development of the tissuespecific lymphocytes is a hard-wired process that targets them to specific tissues for proper functions.

Idioma originalEnglish (US)
Páginas (desde-hasta)7156-7160
Número de páginas5
PublicaciónJournal of Immunology
Volumen185
N.º12
DOI
EstadoPublished - dic 15 2010
Publicado de forma externa

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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