Current serum lipoprotein levels and fMRI response to working memory in midlife

Mitzi M. Gonzales, Takashi Tarumi, Danielle E. Eagan, Hirofumi Tanaka, Fedora O. Biney, Andreana P. Haley

Resultado de la investigación: Articlerevisión exhaustiva

4 Citas (Scopus)


Aims: Given that high cholesterol levels at midlife are a risk factor for future cognitive decline, the goal of the current study was to determine if cholesterol-related alterations in the cerebrovascular response to cognition could be detected at midlife. Methods: Forty adults, aged 40-60 years, performed a 2-Back working memory task during fMRI. The associations between serum total cholesterol, HDL-cholesterol, and total cholesterol/HDL-cholesterol concentrations to task-related activation intensity were modeled using multivariate multiple regression (two-tailed p < 0.02). Results: Higher levels of total cholesterol/HDL-cholesterol related to reduced working memory-related activation intensity in the left inferior parietal lobe, right superior frontal gyrus, and right middle frontal gyrus. Conclusion: These data provide preliminary support for a deleterious effect of elevated total cholesterol/HDL-cholesterol ratio on cerebrovascular support for cognition in midlife.

Idioma originalEnglish (US)
Páginas (desde-hasta)259-267
Número de páginas9
PublicaciónDementia and Geriatric Cognitive Disorders
EstadoPublished - may 2011
Publicado de forma externa

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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