Current concepts in Cryptococcosis

T. F. Patterson, V. T. Andriole

Resultado de la investigación: Review articlerevisión exhaustiva

19 Citas (Scopus)


Cryptococcus neoformans has become an increasingly important pathogen. Cryptococcosis is an important cause of morbidity and mortality in immunocompromised hosts and is the second most common fungal infection complicating AIDS. In recent years, research has focused on the host defenses against Cryptococcus and has led to an improved understanding of the capsular virulence of the organism, the mechanisms of T-cell defenses, and the role of phagocytic cells in the fungistasis and killing of cryptococci. Amphotericin B with or without flucytosine has clearly improved treatment of cryptococcosis, but therapy is associated with significant toxicity. Current investigation is focused on the triazoles, which may offer improved therapy for cryptococcosis. In this report, we review recent developments in the understanding of the host defenses against Cryptococcocus and discuss current recommendations for the management of cryptococcosis.

Idioma originalEnglish (US)
Páginas (desde-hasta)457-465
Número de páginas9
PublicaciónEuropean Journal of Clinical Microbiology & Infectious Diseases
EstadoPublished - may 1989
Publicado de forma externa

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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