TY - JOUR
T1 - Curcumin inhibits the classical and the alternate pathways of complement activation
AU - Kulkarni, Amod P.
AU - Ghebremariam, Yohannes T.
AU - Kotwal, Girish J.
PY - 2005
Y1 - 2005
N2 - Curcumin (Cur), the golden yellow phenolic compound in turmeric, is well studied for its medicinal properties. In the current investigation, Cur dissolved using sodium hydroxide solution (CurNa) was tested for in vitro complement inhibitory activity and compared with rosmarinic acid (RA) and quercetin (Qur) dissolved using sodium hydroxide (RANa and QurNa, respectively) and the vaccinia virus complement control protein (VCP). The comparative study indicated that CurNa inhibited the classical complement pathway dose dependently (IC50 = 404 μM). CurNa was more active than RANa, but less active than QurNa. VCP was about 2,212, 2,786, and 4,520 times more active than QurNa, CurNa, and RANa, respectively. Further study revealed that CurNa dose dependently inhibited zymosan-induced activation of the alternate pathway of complement activation.
AB - Curcumin (Cur), the golden yellow phenolic compound in turmeric, is well studied for its medicinal properties. In the current investigation, Cur dissolved using sodium hydroxide solution (CurNa) was tested for in vitro complement inhibitory activity and compared with rosmarinic acid (RA) and quercetin (Qur) dissolved using sodium hydroxide (RANa and QurNa, respectively) and the vaccinia virus complement control protein (VCP). The comparative study indicated that CurNa inhibited the classical complement pathway dose dependently (IC50 = 404 μM). CurNa was more active than RANa, but less active than QurNa. VCP was about 2,212, 2,786, and 4,520 times more active than QurNa, CurNa, and RANa, respectively. Further study revealed that CurNa dose dependently inhibited zymosan-induced activation of the alternate pathway of complement activation.
KW - Alternate pathway (AP)
KW - Bb
KW - C3b
KW - Classical pathway (CP)
KW - Complement
KW - Curcumin
KW - Hemolysis
KW - Quercetin
KW - Rosmarinic acid
KW - VCP
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U2 - 10.1196/annals.1352.007
DO - 10.1196/annals.1352.007
M3 - Article
C2 - 16387680
AN - SCOPUS:29744460451
SN - 0077-8923
VL - 1056
SP - 100
EP - 112
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
ER -