Curcumin inhibits the classical and the alternate pathways of complement activation

Amod P. Kulkarni, Yohannes T. Ghebremariam, Girish J. Kotwal

Producción científica: Articlerevisión exhaustiva

21 Citas (Scopus)

Resumen

Curcumin (Cur), the golden yellow phenolic compound in turmeric, is well studied for its medicinal properties. In the current investigation, Cur dissolved using sodium hydroxide solution (CurNa) was tested for in vitro complement inhibitory activity and compared with rosmarinic acid (RA) and quercetin (Qur) dissolved using sodium hydroxide (RANa and QurNa, respectively) and the vaccinia virus complement control protein (VCP). The comparative study indicated that CurNa inhibited the classical complement pathway dose dependently (IC50 = 404 μM). CurNa was more active than RANa, but less active than QurNa. VCP was about 2,212, 2,786, and 4,520 times more active than QurNa, CurNa, and RANa, respectively. Further study revealed that CurNa dose dependently inhibited zymosan-induced activation of the alternate pathway of complement activation.

Idioma originalEnglish (US)
Páginas (desde-hasta)100-112
Número de páginas13
PublicaciónAnnals of the New York Academy of Sciences
Volumen1056
DOI
EstadoPublished - 2005
Publicado de forma externa

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology
  • General Neuroscience
  • History and Philosophy of Science

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