Crosstalk between adipose tissue and the heart: An update

Chao Li, Xue Nan Sun, Shangang Zhao, Philipp E. Scherer

Producción científica: Review articlerevisión exhaustiva

7 Citas (Scopus)


It is important to understand how different human organs coordinate and interact with each other. Since obesity and cardiac disease frequently coincide, the crosstalk between adipose tissues and heart has drawn attention. We appreciate that specific peptides/proteins, lipids, nucleic acids, and even organelles shuttle between the adipose tissues and heart. These bioactive components can profoundly affect the metabolism of cells in distal organs, including heart. Importantly, this process can be dysregulated under pathophysiological conditions. This also opens the door to efforts targeting these mediators as potential therapeutic strategies to treat patients who manifest diabetes and cardiovascular disease. Here, we summarize the recent progress toward a better understanding of how the adipose tissues and heart interact with each other.

Idioma originalEnglish (US)
Páginas (desde-hasta)219-226
Número de páginas8
PublicaciónJournal of Translational Internal Medicine
EstadoPublished - sept 1 2022

ASJC Scopus subject areas

  • Internal Medicine


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