Cross-ethnic differences in the severity of neuropsychiatric symptoms in persons with mild cognitive impairment and Alzheimer’s disease

Ricardo Salazar, Alok Kumar Dwivedi, Donald R. Royall

Producción científica: Articlerevisión exhaustiva

31 Citas (Scopus)

Resumen

In this cross-sectional study, we examined the neuropsychiatric profile of mild cognitive impairment (MCI) and Alzheimer’s disease (AD) using the Neuropsychiatric Inventory Questionnaire (NPI-Q). Data were available on 875 controls, 339 MCI cases, and 975 AD participants. Surprisingly, differences in neuropsychiatric symptom (NPS) severity by ethnicity in subjects with AD, but not with MCI, were found. More so, in Hispanics with AD, a higher frequency in most of the individual NPI-Q symptom items of the scale was observed, except for apathy. After adjustment for clinical features, some individual NPI-Q symptoms also showed an association with Hispanic ethnicity in the control group that nearly reached statistical significance. There may be cross-ethnic differences in the neuropsychiatric presentation of AD in Hispanics versus non-Hispanic whites. Future studies are needed to clarify the etiology of these differences, and to assess the need for ethnicity-specific treatment and care-giving interventions.

Idioma originalEnglish (US)
Páginas (desde-hasta)13-21
Número de páginas9
PublicaciónJournal of Neuropsychiatry and Clinical Neurosciences
Volumen29
N.º1
DOI
EstadoPublished - 2017

ASJC Scopus subject areas

  • General Medicine

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