Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain

Yu Shin Kim, Michael Anderson, Kyoungsook Park, Qin Zheng, Amit Agarwal, Catherine Gong, Saijilafu, Le Anne Young, Shaoqiu He, Pamela Colleen LaVinka, Fengquan Zhou, Dwight Bergles, Menachem Hanani, Yun Guan, David C. Spray, Xinzhong Dong

Producción científica: Articlerevisión exhaustiva

202 Citas (Scopus)

Resumen

Primary sensory neurons in the DRG play an essential role in initiating pain by detecting painful stimuli in the periphery. Tissue injury can sensitize DRG neurons, causing heightened pain sensitivity, often leading to chronic pain. Despite the functional importance, how DRG neurons function at a population level is unclear due to the lack of suitable tools. Here we developed an imaging technique that allowed us to simultaneously monitor the activities of >1,600 neurons/DRG in live mice and discovered a striking neuronal coupling phenomenon that adjacent neurons tend to activate together following tissue injury. This coupled activation occurs among various neurons and is mediated by an injury-induced upregulation of gap junctions in glial cells surrounding DRG neurons. Blocking gap junctions attenuated neuronal coupling and mechanical hyperalgesia. Therefore, neuronal coupling represents a new form of neuronal plasticity in the DRG and contributes to pain hypersensitivity by “hijacking” neighboring neurons through gap junctions.

Idioma originalEnglish (US)
Páginas (desde-hasta)1085-1096
Número de páginas12
PublicaciónNeuron
Volumen91
N.º5
DOI
EstadoPublished - sept 7 2016
Publicado de forma externa

ASJC Scopus subject areas

  • General Neuroscience

Huella

Profundice en los temas de investigación de 'Coupled Activation of Primary Sensory Neurons Contributes to Chronic Pain'. En conjunto forman una huella única.

Citar esto