TY - JOUR
T1 - Cost-effectiveness of pravastatin therapy for survivors of myocardial infarction with average cholesterol levels
AU - Tsevat, Joel
AU - Kuntz, Karen M.
AU - Orav, E. John
AU - Weinstein, Milton C.
AU - Sacks, Frank M.
AU - Goldman, Lee
N1 - Funding Information:
Supported by a grant from Bristol-Myers Squibb. The funding agreement ensured the authors’ independence in designing the study, interpreting the data, and writing and publishing the manuscript.
PY - 2001
Y1 - 2001
N2 - Background: The objective of this study was to assess the cost-effectiveness of pravastatin therapy in survivors of myocardial infarction with average cholesterol levels. Methods: We performed a cost-effectiveness analysis based on actual clinical, cost, and health-related quality-of-life data from the Cholesterol and Recurrent Events (CARE) trial. Survival and recurrent coronary heart disease events were modeled from trial data in Markov models, with the use of different assumptions regarding the long-term benefit of therapy. Results: Pravastatin therapy increased quality-adjusted life expectancy at an incremental cost of $16,000 to $32,000 per quality-adjusted life-year gained. In subgroup analyses, the cost-effectiveness of pravastatin therapy was more favorable for patients >60 years of age and for patients with pretreatment low-density lipoprotein cholesterol levels >125 mg/dL. Results were sensitive to the cost of pravastatin and to assumptions about long-term survival benefits from pravastatin therapy. Conclusions: The cost-effectiveness of pravastatin therapy in survivors of myocardial infarction with average cholesterol levels compares favorably with other interventions.
AB - Background: The objective of this study was to assess the cost-effectiveness of pravastatin therapy in survivors of myocardial infarction with average cholesterol levels. Methods: We performed a cost-effectiveness analysis based on actual clinical, cost, and health-related quality-of-life data from the Cholesterol and Recurrent Events (CARE) trial. Survival and recurrent coronary heart disease events were modeled from trial data in Markov models, with the use of different assumptions regarding the long-term benefit of therapy. Results: Pravastatin therapy increased quality-adjusted life expectancy at an incremental cost of $16,000 to $32,000 per quality-adjusted life-year gained. In subgroup analyses, the cost-effectiveness of pravastatin therapy was more favorable for patients >60 years of age and for patients with pretreatment low-density lipoprotein cholesterol levels >125 mg/dL. Results were sensitive to the cost of pravastatin and to assumptions about long-term survival benefits from pravastatin therapy. Conclusions: The cost-effectiveness of pravastatin therapy in survivors of myocardial infarction with average cholesterol levels compares favorably with other interventions.
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U2 - 10.1067/mhj.2001.114805
DO - 10.1067/mhj.2001.114805
M3 - Article
C2 - 11320359
AN - SCOPUS:0035038827
SN - 0002-8703
VL - 141
SP - 727
EP - 734
JO - American Heart Journal
JF - American Heart Journal
IS - 5
ER -