Corticosterone and prolactin response to TFMPP in rats during repeated antidepressant administration

Abstract— The corticosterone and prolactin response to acute administration of the 5‐HT agonist 1‐(m‐trifluoromethylphenyl) piperazine (TFMPP) (10 mg kg⁻¹) was assessed in rats treated for 10 days with either saline, amitriptyline (20 mg kg⁻¹ day⁻¹) or nialamide (40 mg kg⁻¹ day⁻¹). For all groups, TFMPP significantly increased both serum corticosterone and prolactin concentrations compared with control animals challenged with saline. However, the corticosterone response to TFMPP was attenuated significantly by nialamide pretreatment, while the prolactin response to TFMPP was enhanced significantly by amitriptyline pretreatment. These results support previous reports that antidepressants differentially affect 5‐HT‐ergic systems involved in the regulation of corticosterone and prolactin secretion. 1991 Royal Pharmaceutical Society of Great Britain