Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.

J. Lem; A. C. Chin; M. J. Thayer; R. J. Leach; R. E. Fournier

doi:10.1073/pnas.85.19.7302

Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.

J. Lem, A. C. Chin, M. J. Thayer, R. J. Leach, R. E. Fournier

Producción científica: Article › revisión exhaustiva

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Resumen

Tissue-specific extinguisher-1 (Tse-1) is a mouse genetic locus that can repress liver-specific tyrosine aminotransferase gene expression in trans. To search for other Tse-1-responsive genes, hepatoma microcell hybrids retaining mouse chromosome 11 or human chromosome 17, containing murine Tse-1 and human TSE1, respectively, were screened for expression of liver-specific mRNAs. While most liver gene activity was unaffected in such hybrids, phosphoenolpyruvate carboxykinase and tyrosine aminotransferase gene expression was coordinately repressed in these clones. Extinction of both genes was apparently mediated by a single genetic locus that resides on human chromosome 17.

Idioma original	English (US)
Páginas (desde-hasta)	7302-7306
Número de páginas	5
Publicación	Proceedings of the National Academy of Sciences of the United States of America
Volumen	85
N.º	19
DOI	https://doi.org/10.1073/pnas.85.19.7302
Estado	Published - oct 1988
Publicado de forma externa	Sí

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AU - Fournier, R. E.

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AB - Tissue-specific extinguisher-1 (Tse-1) is a mouse genetic locus that can repress liver-specific tyrosine aminotransferase gene expression in trans. To search for other Tse-1-responsive genes, hepatoma microcell hybrids retaining mouse chromosome 11 or human chromosome 17, containing murine Tse-1 and human TSE1, respectively, were screened for expression of liver-specific mRNAs. While most liver gene activity was unaffected in such hybrids, phosphoenolpyruvate carboxykinase and tyrosine aminotransferase gene expression was coordinately repressed in these clones. Extinction of both genes was apparently mediated by a single genetic locus that resides on human chromosome 17.

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Coordinate regulation of two genes encoding gluconeogenic enzymes by the trans-dominant locus Tse-1.

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