Contributions of B cells to lupus pathogenesis

Allison Sang, Ying Yi Zheng, Laurence Morel

Resultado de la investigación: Review articlerevisión exhaustiva

50 Citas (Scopus)


Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.

Idioma originalEnglish (US)
Páginas (desde-hasta)329-338
Número de páginas10
PublicaciónMolecular Immunology
EstadoPublished - dic 1 2014
Publicado de forma externa

ASJC Scopus subject areas

  • Immunology
  • Molecular Biology


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