Resumen
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.
Idioma original | English (US) |
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Páginas (desde-hasta) | 329-338 |
Número de páginas | 10 |
Publicación | Molecular Immunology |
Volumen | 62 |
N.º | 2 |
DOI | |
Estado | Published - dic 1 2014 |
Publicado de forma externa | Sí |
ASJC Scopus subject areas
- Immunology
- Molecular Biology