TY - JOUR
T1 - Contractile properties of cultured glomerular mesangial cells
AU - Kreisberg, J. I.
AU - Venkatachalam, M.
AU - Troyer, D.
PY - 1985
Y1 - 1985
N2 - The glomerular mesangium is composed of matrix material and at least two cell types. One is a bone marrow-derived phagocyte and the other is a smooth muscle-like cell. The phagocytic cell represents approximately 3-7% of the total mesangial cell population. The other, more abundant, cell type appears to be contractile and therefore has been proposed to play a role in regulating the surface area for filtration, one component of the ultrafiltration coefficient, K[f]. In this review we discuss the contractile properties of cultured mesangial cells as well as the phenotypic alterations that lead to loss of isotonic contraction after prolonged culture.
AB - The glomerular mesangium is composed of matrix material and at least two cell types. One is a bone marrow-derived phagocyte and the other is a smooth muscle-like cell. The phagocytic cell represents approximately 3-7% of the total mesangial cell population. The other, more abundant, cell type appears to be contractile and therefore has been proposed to play a role in regulating the surface area for filtration, one component of the ultrafiltration coefficient, K[f]. In this review we discuss the contractile properties of cultured mesangial cells as well as the phenotypic alterations that lead to loss of isotonic contraction after prolonged culture.
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U2 - 10.1152/ajprenal.1985.249.4.f457
DO - 10.1152/ajprenal.1985.249.4.f457
M3 - Article
C2 - 2996365
AN - SCOPUS:0022137599
SN - 0363-6127
VL - 18
SP - F457-F463
JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology
IS - 4
ER -