Continuous light paradoxically reduces catecholamine-induced melatonin production

William E. Heydorn; Irwin Lucki; Alan Frazer

doi:10.1016/0006-8993(83)91054-5

Continuous light paradoxically reduces catecholamine-induced melatonin production

William E. Heydorn, Irwin Lucki, Alan Frazer

Producción científica: Article › revisión exhaustiva

2 Citas (Scopus)

Resumen

Exposure of rats to continuous light for 14 days reduced the stimulation of melatonin content in the pineal gland produced by either isoproterenol administration or exposure to darkness. Since continuous light has been reported to enhance many intermediate biochemical events leading to the synthesis of melatonin, these results demonstrate the importance of examining the end-product of an organ when evaluating the physiological significance of biochemical changes in model biological systems.

Idioma original	English (US)
Páginas (desde-hasta)	175-178
Número de páginas	4
Publicación	Brain Research
Volumen	267
N.º	1
DOI	https://doi.org/10.1016/0006-8993(83)91054-5
Estado	Published - may 9 1983
Publicado de forma externa	Sí

ASJC Scopus subject areas

Clinical Neurology
Molecular Biology
General Neuroscience
Developmental Biology

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title = "Continuous light paradoxically reduces catecholamine-induced melatonin production",

abstract = "Exposure of rats to continuous light for 14 days reduced the stimulation of melatonin content in the pineal gland produced by either isoproterenol administration or exposure to darkness. Since continuous light has been reported to enhance many intermediate biochemical events leading to the synthesis of melatonin, these results demonstrate the importance of examining the end-product of an organ when evaluating the physiological significance of biochemical changes in model biological systems.",

keywords = "beta-receptors, continuous light, isoproterenol, norepinephrine, pineal gland",

author = "Heydorn, {William E.} and Irwin Lucki and Alan Frazer",

note = "Funding Information: This research was supported by research funds from the Veterans Administration, NIMH Grant MH 29094 (A.F.), and a fellowship from the American Foundation for Pharmaceutical Education (W.H.). We are grateful to Dr. Benjamin Weiss for his critical comments concerning earlier versions of this manuscript and to Patricia Boyle for typing the manuscript. William Heydorn is currently at: NIMH, Building 10, Room 3D48, Bethesda, MD 20205.",

year = "1983",

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doi = "10.1016/0006-8993(83)91054-5",

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T1 - Continuous light paradoxically reduces catecholamine-induced melatonin production

AU - Heydorn, William E.

AU - Lucki, Irwin

AU - Frazer, Alan

N1 - Funding Information: This research was supported by research funds from the Veterans Administration, NIMH Grant MH 29094 (A.F.), and a fellowship from the American Foundation for Pharmaceutical Education (W.H.). We are grateful to Dr. Benjamin Weiss for his critical comments concerning earlier versions of this manuscript and to Patricia Boyle for typing the manuscript. William Heydorn is currently at: NIMH, Building 10, Room 3D48, Bethesda, MD 20205.

PY - 1983/5/9

Y1 - 1983/5/9

N2 - Exposure of rats to continuous light for 14 days reduced the stimulation of melatonin content in the pineal gland produced by either isoproterenol administration or exposure to darkness. Since continuous light has been reported to enhance many intermediate biochemical events leading to the synthesis of melatonin, these results demonstrate the importance of examining the end-product of an organ when evaluating the physiological significance of biochemical changes in model biological systems.

AB - Exposure of rats to continuous light for 14 days reduced the stimulation of melatonin content in the pineal gland produced by either isoproterenol administration or exposure to darkness. Since continuous light has been reported to enhance many intermediate biochemical events leading to the synthesis of melatonin, these results demonstrate the importance of examining the end-product of an organ when evaluating the physiological significance of biochemical changes in model biological systems.

KW - beta-receptors

KW - continuous light

KW - isoproterenol

KW - norepinephrine

KW - pineal gland

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Continuous light paradoxically reduces catecholamine-induced melatonin production

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ASJC Scopus subject areas

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