Constitutional mechanisms of vulnerability and resilience to nicotine dependence

N. Hiroi, D. Scott

Resultado de la investigación: Review articlerevisión exhaustiva

20 Citas (Scopus)


The core nature of nicotine dependence is evident in wide variations in how individuals become and remain smokers. Individuals with pre-existing behavioral traits are more likely to develop nicotine dependence and experience difficulty when attempting to quit. Many molecular factors likely contribute to individual variations in the development of nicotine dependence and behavioral traits in complex manners. However, the identification of such molecules has been hampered by the phenotypic complexity of nicotine dependence and the complex ways molecules affect elements of nicotine dependence. We hypothesize that nicotine dependence is, in part, a result of interactions between nicotine and pre-existing behavioral traits. This perspective suggests that the identification of the molecular bases of such pre-existing behavioral traits will contribute to the development of effective methods for reducing smoking dependence and for helping smokers to quit.

Idioma originalEnglish (US)
Páginas (desde-hasta)653-667
Número de páginas15
PublicaciónMolecular psychiatry
EstadoPublished - jul. 2009
Publicado de forma externa

ASJC Scopus subject areas

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Psychiatry and Mental health


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