Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

Michael B. Mattammal; Hyung D. Chung; Randy Strong; Fong Fu Hsu

doi:10.1016/0378-4347(93)80310-Z

Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

Michael B. Mattammal, Hyung D. Chung, Randy Strong, Fong Fu Hsu

Producción científica: Article › revisión exhaustiva

34 Citas (Scopus)

Resumen

Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.

Idioma original	English (US)
Páginas (desde-hasta)	205-212
Número de páginas	8
Publicación	Journal of Chromatography B: Biomedical Sciences and Applications
Volumen	614
N.º	2
DOI	https://doi.org/10.1016/0378-4347(93)80310-Z
Estado	Published - may 5 1993
Publicado de forma externa	Sí

ASJC Scopus subject areas

General Chemistry

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title = "Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry",

abstract = "Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.",

author = "Mattammal, {Michael B.} and Chung, {Hyung D.} and Randy Strong and Hsu, {Fong Fu}",

note = "Funding Information: This work was supported by the Department of Veterans Affairs. Mass spectraw ere obtained at the Center of Mass Spectrometry Resource, Washington University School of Medicine which is supported by NIH Grants RR-00954 and AM-20579.",

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doi = "10.1016/0378-4347(93)80310-Z",

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AU - Mattammal, Michael B.

AU - Chung, Hyung D.

AU - Strong, Randy

AU - Hsu, Fong Fu

N1 - Funding Information: This work was supported by the Department of Veterans Affairs. Mass spectraw ere obtained at the Center of Mass Spectrometry Resource, Washington University School of Medicine which is supported by NIH Grants RR-00954 and AM-20579.

PY - 1993/5/5

Y1 - 1993/5/5

N2 - Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.

AB - Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.

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Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

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