Confirmation of a dopamine metabolite in parkinsonian brain tissue by gas chromatography-mass spectrometry

Michael B. Mattammal, Hyung D. Chung, Randy Strong, Fong Fu Hsu

Resultado de la investigación: Articlerevisión exhaustiva

31 Citas (Scopus)

Resumen

Gas chromatography-mass spectrometry was used to identify a dopamine metabolite isolated from the substantia nigra of parkinsonian brain tissue. Incubation of dopamine with monoamine oxidase B gave the same product which was identified as 3,4-dihydroxyphenylacetaldehyde. The structure of the compound was established by chemical synthesis, metastable ion measurement and high-resolution mass spectrometry.

Idioma originalEnglish (US)
Páginas (desde-hasta)205-212
Número de páginas8
PublicaciónJournal of Chromatography B: Biomedical Sciences and Applications
Volumen614
N.º2
DOI
EstadoPublished - may. 5 1993
Publicado de forma externa

ASJC Scopus subject areas

  • Chemistry(all)

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