TY - JOUR
T1 - Concomitant transfer of BCG-CW and canine virus antibodies from dams to pups
AU - Winters, Wendell D.
AU - Clouse, William J.
AU - Harris, Steven C.
N1 - Funding Information:
We thank Dr. Ronald E. Paque for his constructive suggestions and comments. This study was funded in part from NIH, NCI CB 84248 and the Veterans Administration.
PY - 1981
Y1 - 1981
N2 - Levels of antibodies against infectious canine hepatitis virus (ICHV) and Bacillus Calmette-Guérin cell wall (BCG-CW) antigens in sera from BCG-CW inoculated dams, uninoculated dams, neonate pups in litters born to these dams and normal female dogs were measured by solid phase bead-type radioimmunoassay (SBRIA) tests. Significantly higher levels of antibodies reactive with BCG-CW, but not ICHV, antigens were found in the sera from two day old pups born to BCG-CW inoculated, ICHV-immune dams than in sera from two day old pups born to ICHV-immune dams not inoculated with BCG-CW. These results demonstrate that maternal antibodies against antigens of a non-viable immunotherapeutically active preparation (BCG-CW), and against antigens of ICHV, a canine virus routinely used in vaccines, can be passively transferred from dams to newborn pups.
AB - Levels of antibodies against infectious canine hepatitis virus (ICHV) and Bacillus Calmette-Guérin cell wall (BCG-CW) antigens in sera from BCG-CW inoculated dams, uninoculated dams, neonate pups in litters born to these dams and normal female dogs were measured by solid phase bead-type radioimmunoassay (SBRIA) tests. Significantly higher levels of antibodies reactive with BCG-CW, but not ICHV, antigens were found in the sera from two day old pups born to BCG-CW inoculated, ICHV-immune dams than in sera from two day old pups born to ICHV-immune dams not inoculated with BCG-CW. These results demonstrate that maternal antibodies against antigens of a non-viable immunotherapeutically active preparation (BCG-CW), and against antigens of ICHV, a canine virus routinely used in vaccines, can be passively transferred from dams to newborn pups.
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U2 - 10.1016/0145-305X(81)90039-2
DO - 10.1016/0145-305X(81)90039-2
M3 - Article
C2 - 6263724
AN - SCOPUS:0019499376
SN - 0145-305X
VL - 5
SP - 321
EP - 328
JO - Developmental and Comparative Immunology
JF - Developmental and Comparative Immunology
IS - 2
ER -