TY - GEN
T1 - Computer model of ocular hydrodynamics
AU - Kiel, J. W.
PY - 1999/12/1
Y1 - 1999/12/1
N2 - This paper describes a mathematical model of the fluid movements in eye responsible for the generation of the intraocular pressure (IOP). The model was written in STELLA (High Performance Systems), and includes: ciliary and choroidal hemodynamics, the Starling equilibria for ciliary capillary ultrafiltration and passive fluid flux across the non-pigment epithelium (NPE), active secretion via generation of an osmotic gradient across the NPE, aqueous outflow via trabecular and uveoscleral pathways, and the IOP. Model simulations were verified experimentally or are consistent with in vitro studies and current concepts of aqueous dynamics. The model is useful for teaching ocular hydrodynamics and generating experimental hypotheses.
AB - This paper describes a mathematical model of the fluid movements in eye responsible for the generation of the intraocular pressure (IOP). The model was written in STELLA (High Performance Systems), and includes: ciliary and choroidal hemodynamics, the Starling equilibria for ciliary capillary ultrafiltration and passive fluid flux across the non-pigment epithelium (NPE), active secretion via generation of an osmotic gradient across the NPE, aqueous outflow via trabecular and uveoscleral pathways, and the IOP. Model simulations were verified experimentally or are consistent with in vitro studies and current concepts of aqueous dynamics. The model is useful for teaching ocular hydrodynamics and generating experimental hypotheses.
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M3 - Conference contribution
AN - SCOPUS:0033351111
SN - 0780356756
T3 - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
BT - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PB - IEEE
T2 - Proceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
Y2 - 13 October 1999 through 16 October 1999
ER -