Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy

Chifeng Ma; Yufei Huang; Huang I. Harry; Yidong Chen

doi:10.1109/BIBMW.2011.6112555

Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy

Chifeng Ma, Yufei Huang, Huang I. Harry, Yidong Chen

Producción científica: Conference contribution

Resumen

This work aims at addressing the problems existed in the original cMap algorithm and proposed a new drug Mode-of Action Network construction scheme including data pre-processing, signature gene extraction, network construction and query prediction. Multiple analyses were conducted to investigate the structure of constructed drug mode-of-action network and the cMap based Mode-of-Action network is tested on the independent drug treatment datasets. All result shows our cMap based drug Mode-of-Action network is both statistically and biologically significant and out-perform the original cMap project.

Idioma original	English (US)
Título de la publicación alojada	2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
Páginas	1045-1047
Número de páginas	3
DOI	https://doi.org/10.1109/BIBMW.2011.6112555
Estado	Published - 2011
Evento	2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 - Atlanta, GA, United States Duración: nov 12 2011 → nov 15 2011

Serie de la publicación

Nombre	2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011

Other

Other	2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
País/Territorio	United States
Ciudad	Atlanta, GA
Período	11/12/11 → 11/15/11

ASJC Scopus subject areas

Biomedical Engineering
Health Informatics
Health Information Management

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10.1109/BIBMW.2011.6112555

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Ma, C., Huang, Y., Harry, H. I., & Chen, Y. (2011). Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy. En 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011 (pp. 1045-1047). Artículo 6112555 (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011). https://doi.org/10.1109/BIBMW.2011.6112555

Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy. / Ma, Chifeng; Huang, Yufei; Harry, Huang I. et al.
2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. 2011. p. 1045-1047 6112555 (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011).

Producción científica: Conference contribution

Ma, C, Huang, Y, Harry, HI & Chen, Y 2011, Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy. En 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011., 6112555, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011, pp. 1045-1047, 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011, Atlanta, GA, United States, 11/12/11. https://doi.org/10.1109/BIBMW.2011.6112555

Ma C, Huang Y, Harry HI, Chen Y. Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy. En 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. 2011. p. 1045-1047. 6112555. (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011). doi: 10.1109/BIBMW.2011.6112555

Ma, Chifeng ; Huang, Yufei ; Harry, Huang I. et al. / Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy. 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011. 2011. pp. 1045-1047 (2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011).

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abstract = "This work aims at addressing the problems existed in the original cMap algorithm and proposed a new drug Mode-of Action Network construction scheme including data pre-processing, signature gene extraction, network construction and query prediction. Multiple analyses were conducted to investigate the structure of constructed drug mode-of-action network and the cMap based Mode-of-Action network is tested on the independent drug treatment datasets. All result shows our cMap based drug Mode-of-Action network is both statistically and biologically significant and out-perform the original cMap project.",

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Comprehensive investigation of connectivity map data-towards a drug mode of action network for personalized thnerapy

Resumen

Serie de la publicación

Other

ASJC Scopus subject areas

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